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viral interferon regulatory factors

viral encoded members of the IRF family
Also Known As:
IRF1 protein, Human herpesvirus 8; IRF2 protein, Human herpesvirus 8; IRF3 protein, Human herpesvirus 8; IRF4 protein, Human herpesvirus 8; K9 protein, HHV-8; interferon regulatory factor 1, Human herpesvirus 8; interferon regulatory factor 2, Human herpesvirus 8; interferon regulatory factor 3, Human herpesvirus 8; interferon regulatory factor 4, Human herpesvirus 8; interferon regulatory factor, viral; interferon regulatory factor-1, viral; interferon regulatory factor-3, viral; interferon regulatory factors, viral; vIRF; vIRF-1 protein, KHSV; vIRF-1 protein, Kaposi's sarcoma-associated herpesvirus; vIRF-2 protein, KHSV; vIRF-2 protein, Kaposi's sarcoma-associated herpesvirus; vIRF-3; vIRF-3 protein, KHSV; vIRF-3 protein, Kaposi's sarcoma-associated herpesvirus; vIRF-4 protein, KHSV; vIRF-4 protein, Kaposi's sarcoma-associated herpesvirus; vIRF1; vIRF3; viral IRF; viral interferon regulatory factor; viral interferon regulatory factor-1; viral interferon regulatory factor-3
Networked: 76 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Gao, Shou-Jiang: 6 articles (11/2022 - 01/2018)
2. Jung, Jae U: 6 articles (01/2018 - 03/2006)
3. Li, Wan: 5 articles (11/2022 - 01/2019)
4. Lu, Chun: 5 articles (11/2022 - 01/2019)
5. Yan, Qin: 5 articles (11/2022 - 01/2019)
6. Qi, Xiaoyu: 4 articles (11/2022 - 01/2020)
7. Wang, Fei: 4 articles (05/2021 - 01/2019)
8. Nicholas, John: 4 articles (01/2020 - 01/2007)
9. Citovsky, Vitaly: 4 articles (01/2018 - 03/2010)
10. Chen, Yuheng: 3 articles (05/2021 - 01/2020)

Related Diseases

1. Neoplasms (Cancer)
2. Infections
3. Primary Effusion Lymphoma
4. Kaposi Sarcoma (Kaposi's Sarcoma)
06/29/2022 - "In this review, we describe the most important KSHV genes [ORF 73 (LANA), ORF 72 (vCyclin), ORF 71 or ORFK13 (vFLIP), ORF 74 (vGPCR), ORF 16 (vBcl-2), ORF K2 (vIL-6), ORF K9 (vIRF 1)/ORF K10.5, ORF K10.6 (vIRF 3), ORF K1 (K1), ORF K15 (K15), and ORF 36 (vPK)] that have the potential to induce malignant phenotypic characteristics of Kaposi's sarcoma. "
02/15/2007 - "Kaposi sarcoma herpesvirus-encoded vFLIP and vIRF1 regulate antigen presentation in lymphatic endothelial cells."
06/22/2018 - "The hepatitis B virus (HBV) HBx and the human T cell lymphotropic virus-1 (HTLV-1) Tax proteins inhibit p53 activity through the modulation of p300/CBP nuclear factors, while the Kaposi's sarcoma herpesvirus (HHV8) LANA, vIRF-1 and vIRF-3 proteins have been shown to destabilize the oncosuppressor, causing a decrease in its levels in the infected cells. "
01/01/2018 - "This study is the first to identify latent and lytic functions of vIRF-1 and vIRF-3, respectively, and to address the biological activities of these vIRFs through their interactions with USP7.IMPORTANCE HHV-8 is associated with Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease; both latent and lytic viral functions are believed to contribute. "
02/01/2014 - "Kaposi's sarcoma-associated herpesvirus (KSHV), the etiological agent of Kaposi's sarcoma and primary effusion lymphoma, has developed a unique mechanism to deregulate host antiviral innate immunity and growth control by incorporating four viral homologs (vIRF1 to -4) of cellular IRFs into its genome. "
5. Bacillary Dysentery (Shigellosis)

Related Drugs and Biologics

1. Secretory Immunoglobulin A (SIgA)
2. Anti-Bacterial Agents (Antibiotics)
3. viral interferon regulatory factors
4. Proteins (Proteins, Gene)
5. DNA (Deoxyribonucleic Acid)
6. Cytokines
7. Interleukin-6 (Interleukin 6)
8. Transcription Factors (Transcription Factor)
9. Antiviral Agents (Antivirals)
10. Lymphoid Enhancer-Binding Factor 1

Related Therapies and Procedures

1. Therapeutics