|1.||Deeb, Dorrah: 13 articles (01/2013 - 01/2008)|
|2.||Gao, Xiaohua: 13 articles (01/2013 - 01/2008)|
|3.||Gautam, Subhash C: 13 articles (01/2013 - 01/2008)|
|4.||Arbab, Ali S: 9 articles (01/2013 - 02/2010)|
|5.||Liu, Yongbo: 9 articles (01/2013 - 03/2010)|
|6.||Dulchavsky, Scott A: 8 articles (11/2011 - 01/2008)|
|7.||Sporn, Michael B: 7 articles (07/2015 - 05/2007)|
|8.||Liby, Karen T: 6 articles (07/2015 - 05/2007)|
|9.||Sporn, M B: 4 articles (05/2001 - 05/2000)|
|10.||Bishayee, Anupam: 3 articles (08/2015 - 09/2013)|
10/01/2015 - "Various previous studies have demonstrated that oleanane triterpenoids exhibit cytotoxic activity against various types of cancer cells. "
11/01/2011 - "Synthetic oleanane triterpenoids are novel agents which have shown strong antitumorigenic activity against a wide range of cancer types in vitro. "
07/01/2009 - "Cancer chemopreventive activity of oleanane-type triterpenoids from the stem bark of Betula ermanii."
05/04/2000 - "We initially randomly synthesized about 60 oleanane and ursane triterpenoids as potential anti-inflammatory and cancer chemopreventive agents. "
09/15/1988 - "Inhibition of the tumor-promoting action of 12-O-tetradecanoylphorbol-13-acetate by some oleanane-type triterpenoid compounds."
|2.||Prostatic Neoplasms (Prostate Cancer)
01/06/2012 - "Our previous studies have shown that methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me), a oleanane synthetic triterpenoid induces apoptosis in prostate cancer cells by inhibiting the Akt/NF-κB/mTOR signaling cascade; however, the mechanism by which CDDO-Me inhibits Akt/NF-κB/mTOR signaling has remained undetermined. "
06/01/2009 - "The goal of this study was to determine the antitumor activity and the mechanism of action of methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me), a oleanane-derived synthetic triterpenoid for human prostate cancer cells. "
01/01/2013 - "Here, we used human prostate cancer DU-145 cells as an in vitro model to elucidate the synergy of the interactions between biological activities of an oleanane type 13β,28-epoxy triterpene saponoside (Lclet 4) and mitoxantrone, which is a cytostatic drug commonly used in prostate cancer therapy. "
01/01/2011 - "Prevention of Prostate Cancer with Oleanane Synthetic Triterpenoid CDDO-Me in the TRAMP Mouse Model of Prostate Cancer."
02/01/2010 - "Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism."
|3.||Kidney Diseases (Kidney Disease)
01/01/2014 - "Bardoxolone methyl, an Nrf2-activating and nuclear factor-κB-inhibiting semisynthetic oleanane triterpenoid compound, was evaluated in a phase 3 trial (BEACON) in patients with type 2 diabetes mellitus (T2DM) and stage 4 chronic kidney disease (CKD). "
04/05/2013 - "Bardoxolone methyl (2-cyano-3,12-dioxooleane-1,9(11)-dien-28-oic acid methyl ester; CDDO-Me) (1), a synthetic oleanane triterpenoid with highly potent anti-inflammatory activity (levels below 1 nM), has completed a successful phase I clinical trial for the treatment of cancer and a successful phase II trial for the treatment of chronic kidney disease in type 2 diabetes patients. "
|4.||Pancreatic Neoplasms (Pancreatic Cancer)
03/15/2014 - "We identified a novel synthetic oleanane triterpenoid compound designated AMR-MeOAc that effectively kills K-Ras mutant pancreatic cancer HPAF-II cells. "
03/15/2014 - "Novel synthetic oleanane triterpenoid AMR-MeOAc inhibits K-Ras through ERK, Akt and survivin in pancreatic cancer cells."
11/01/2010 - "These results suggest that oleanane triterpenoids and rexinoids have the potential to prevent pancreatic cancer."
11/01/2010 - "We tested two promising classes of noncytotoxic drugs, synthetic oleanane triterpenoids and rexinoids, for the prevention of carcinogenesis in the highly relevant LSL-Kras(G12D/+);LSL-Trp53(R127H/+);Pdx-1-Cre (KPC) mouse model of pancreatic cancer. "
12/01/2010 - "In this study, we evaluated the antitumor activity and the mechanism of action of methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me), a oleanane-derived synthetic triterpenoid for human pancreatic cancer cell lines. "
|5.||Colorectal Neoplasms (Colorectal Cancer)
01/01/2011 - "CDDO-Me, an oleanane synthetic triterpenoid has shown strong antitumorigeic activity towards diverse cancer cell types including colorectal cancer cells. "
03/01/2010 - "In the present study, we tested the apoptosis-inducing activity of oleanane triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) and its C-28 methyl ester (CDDO-Me) and C-28 imidazole (CDDO-Im) derivatives in colorectal cancer cells lines. "
|2.||1- (2- cyano- 3,12- dioxooleana- 1,9- dien- 28- oyl) imidazole
|2.||Traditional Medicine (Folk Remedies)
|3.||Drug Therapy (Chemotherapy)