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topsentin A

number of carbony group = 1 for topsentin A and no carbonyl group for nortopsentin B and D; structure in first source

Also Known As:

nortopsentin B; nortopsentin D

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - topsentin A: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - topsentin A: 2

Experts

1.	Hwang, Jiyoung: 1 article (01/2020)
2.	Kim, Donghwa: 1 article (01/2020)
3.	Lee, Sang Kook: 1 article (01/2020)
4.	Park, Hyen Joo: 1 article (01/2020)
5.	Park, Jae Sung: 1 article (01/2020)
6.	Shin, Jongheon: 1 article (01/2020)

Related Diseases

1.	Neoplasms (Cancer) 01/29/2020 - "Topsentin, a bis(indolyl)imidazole alkaloid isolated from the marine sponge Spongosorites genitrix, has been reported to exhibit anti-tumor and anti-microbial activities. " 07/25/1991 - "Topsentin, a bis(indolyl)imidazole marine natural product, inhibited the proliferation of cultured human and murine tumor cells at micromolar concentrations (IC50 values ranged from 4 to 40 microM) and was active against in vivo P388 leukemia (%T/C = 137, 150 mg/kg, QD1-5) and B16 melanoma (%T/C = 144, 37.5 mg/kg, QD1-9) tumors. "
2.	Experimental Melanoma 07/25/1991 - "Topsentin, a bis(indolyl)imidazole marine natural product, inhibited the proliferation of cultured human and murine tumor cells at micromolar concentrations (IC50 values ranged from 4 to 40 microM) and was active against in vivo P388 leukemia (%T/C = 137, 150 mg/kg, QD1-5) and B16 melanoma (%T/C = 144, 37.5 mg/kg, QD1-9) tumors. "
3.	Leukemia P388 07/25/1991 - "Topsentin, a bis(indolyl)imidazole marine natural product, inhibited the proliferation of cultured human and murine tumor cells at micromolar concentrations (IC50 values ranged from 4 to 40 microM) and was active against in vivo P388 leukemia (%T/C = 137, 150 mg/kg, QD1-5) and B16 melanoma (%T/C = 144, 37.5 mg/kg, QD1-9) tumors. "

Related Drugs and Biologics

1.	imidazole
2.	Alkaloids
3.	C 137