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1-methylpropyl-2-imidazolyl disulfide

a thioredoxin inhibitor with antineoplastic activity

Also Known As:

2-((1-methylpropyl)dithio)-1H-imidazole; IV 2 compound; IV-2 compound; PX-12 compound; PX12 compound

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Barsoum, Sylviana: 1 article (01/2013)
2.	Chi, Oak Z: 1 article (01/2013)
3.	Grayson, Jeremy: 1 article (01/2013)
4.	Liu, Xia: 1 article (01/2013)
5.	Weiss, Harvey R: 1 article (01/2013)
6.	Lazo, J S: 1 article (09/2000)
7.	Tamura, K: 1 article (09/2000)
8.	Vogt, A: 1 article (09/2000)
9.	Watson, S: 1 article (09/2000)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2000 - "The redox-active, asymmetrical 1-methylpropyl-2-imidazolyl disulfide (IV-2) has previously been shown to react with and inhibit thioredoxin activity in vitro, the proliferation of human tumor cells in culture, and the growth of tumors in mice. " 01/01/2013 - "Since a thioredoxin-1 (Trx-1) inhibitor, 1-methylpropyl-2-imidazolyl disulfide (PX-12) which is an antitumor agent, significantly decreased vascular permeability in tumor xenografts within a few hours of treatment, we tested whether PX-12 would attenuate blood-brain barrier (BBB) disruption in the early stage of focal cerebral ischemia and whether its action could be affected by vascular endothelial growth factor (VEGF) which interacts with the Trx-1 system. "
2.	Brain Ischemia (Cerebral Ischemia) 01/01/2013 - "Since a thioredoxin-1 (Trx-1) inhibitor, 1-methylpropyl-2-imidazolyl disulfide (PX-12) which is an antitumor agent, significantly decreased vascular permeability in tumor xenografts within a few hours of treatment, we tested whether PX-12 would attenuate blood-brain barrier (BBB) disruption in the early stage of focal cerebral ischemia and whether its action could be affected by vascular endothelial growth factor (VEGF) which interacts with the Trx-1 system. "

Related Drugs and Biologics

1.	Thioredoxins
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Antineoplastic Agents (Antineoplastics)