|1.||Wehrens, Xander H T: 6 articles (11/2014 - 06/2007)|
|2.||Song, Long-Sheng: 5 articles (10/2015 - 08/2010)|
|3.||Landstrom, Andrew P: 5 articles (11/2014 - 06/2007)|
|4.||Takeshima, Hiroshi: 4 articles (10/2015 - 12/2004)|
|5.||Ackerman, Michael J: 4 articles (11/2014 - 06/2007)|
|6.||Chen, Biyi: 4 articles (08/2014 - 08/2010)|
|7.||Margolis, Russell L: 4 articles (02/2012 - 05/2002)|
|8.||Weiss, Robert M: 3 articles (08/2014 - 08/2010)|
|9.||Guo, Ang: 3 articles (08/2014 - 08/2010)|
|10.||Wang, Shi-Qiang: 3 articles (05/2013 - 07/2009)|
11/19/2013 - "This study sought to study the role of junctophilin-2 (JPH2) in atrial fibrillation (AF). "
11/19/2013 - "Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization."
11/19/2013 - "Ca(2+) leak in atrial fibrillation: junctophilin-2 stabilizes ryanodine receptor."
|2.||Huntington Disease (Huntington's Disease)
10/01/2015 - "A CAG/CTG repeat expansion in the junctophilin-3 (JPH3) gene on chromosome 16q24.2 causes a Huntington disease-like phenotype (HDL2). "
10/01/2015 - "Junctophilin 3 (JPH3) expansion mutations causing Huntington disease like 2 (HDL2) are common in South African patients with African ancestry and a Huntington disease phenotype."
02/01/2012 - "Loss of junctophilin-3 contributes to Huntington disease-like 2 pathogenesis."
05/12/2011 - "Huntington's disease-like-2 (HDL2) is a phenocopy of Huntington's disease caused by CTG/CAG repeat expansion at the Junctophilin-3 (JPH3) locus. "
03/01/2007 - "Huntington's disease-like 2 (HDL2) is caused by a CAG/CTG expansion mutation on chromosome 16q24.3. The repeat falls, in the CTG orientation, within a variably spliced exon of junctophilin-3 (JPH3). "
08/19/2014 - "Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress."
06/01/2014 - "Increasing evidence suggests that T-tubule remodeling due to junctophilin-2 (JP-2) downregulation plays a critical role in the progression of heart failure. "
04/29/2014 - "Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure."
07/01/2009 - "Many human diseases such as heart failure accompany with junctophilin mutations, so junctophilin may become a new target against these diseases."
06/01/2001 - "Mutant mice lacking the cardiac-type junctophilin exhibited embryonic lethality due to heart failure, and the mutant cardiac myocytes showed deficiency of the junctional membrane complexes and abnormal Ca(2+) signaling."
04/27/2012 - "Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2+ entry via Orai1."
08/20/2010 - "We sought to examine (1) whether pathological T-tubule remodeling occurs early in compensated hypertrophy and, if so, how it evolves during the transition from hypertrophy to HF; and (2) the role of junctophilin-2 in T-tubule remodeling. "
03/01/2011 - "Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling."
02/15/2013 - "During the transition from compensated hypertrophy to heart failure, the signaling between L-type Ca(2+) channels in the cell membrane/T-tubules and ryanodine receptors in the sarcoplasmic reticulum becomes defective, partially because of the decreased expression of a T-tubule-sarcoplasmic reticulum anchoring protein, junctophilin-2. "
|5.||Hypertrophic Cardiomyopathy (Asymmetric Septal Hypertrophy)
06/01/2007 - "Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans."
01/01/2007 - "Mutation of junctophilin type 2 associated with hypertrophic cardiomyopathy."
10/01/2015 - "Human genetic mutations in junctophilin subtypes are linked to congenital hypertrophic cardiomyopathy and neurodegenerative diseases. "
12/01/2013 - "Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response."
|1.||Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)
|4.||Proteins (Proteins, Gene)