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cyclo(cysteinyl- glutaminyl- isoleucyl- tryptophyl- lysyl- glutaminyl- lysyl- prolyl- aspartyl- leucyl- cysteinyl- amide)

NR58-3.14.3 & NR58-3.14.5 are stereoisomers

Also Known As:

NR58-3.14.3; NR58-3.14.5; cyclo(CQIWKPDLC-NH2); cyclo(Cys-Gln-Ile-Trp-Lys-Gln-Lys-Pro-Asp-Leu-Cys-NH2)

Networked: 6 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - cyclo(cysteinyl-glutaminyl-isoleucyl-tryptophyl-lysyl-glutaminyl-lysyl-prolyl-aspartyl-leucyl-cysteinyl-amide): 6
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - cyclo(cysteinyl-glutaminyl-isoleucyl-tryptophyl-lysyl-glutaminyl-lysyl-prolyl-aspartyl-leucyl-cysteinyl-amide): 6

Experts

1.	Grainger, D J: 2 articles (06/2001 - 06/2001)
2.	Reckless, J: 2 articles (06/2001 - 06/2001)
3.	Fernando, Nilisha: 1 article (02/2016)
4.	Natoli, Riccardo: 1 article (02/2016)
5.	Provis, Jan: 1 article (02/2016)
6.	Rutar, Matt: 1 article (02/2016)
7.	Valter, Krisztina: 1 article (02/2016)
8.	Andreesen, Reinhard: 1 article (04/2009)
9.	Bouazzaoui, Abdellatif: 1 article (04/2009)
10.	Chang, Yayi: 1 article (04/2009)

Related Diseases

1.	Reperfusion Injury 01/01/2004 - "This study was undertaken to define the pattern of chemokine expression in lung ischemia-reperfusion injury (LIRI), and to determine whether a broad-spectrum chemokine inhibitor, NR58-3.14.3, could confer significant protection against LIRI. " 06/01/2001 - "In the current study, the authors investigate the neuroprotective action of NR58-3.14.3, a novel broad-spectrum inhibitor of chemokine function (both CXC and CC types), in a rat model of cerebral ischemia-reperfusion injury. "
2.	Retinal Degeneration 02/24/2016 - "Our findings indicate that NR58-3.14.3 is effective in inhibiting subretinal macrophage accumulation in light-induced retinal degeneration and illustrate the potential of broad-spectrum chemokine inhibitors as novel therapeutic agents in thwarting retinal inflammation. "
3.	Inflammation (Inflammations) 02/24/2016 - "The broad-spectrum chemokine inhibitor NR58-3.14.3 modulates macrophage-mediated inflammation in the diseased retina." 02/24/2016 - "Our findings indicate that NR58-3.14.3 is effective in inhibiting subretinal macrophage accumulation in light-induced retinal degeneration and illustrate the potential of broad-spectrum chemokine inhibitors as novel therapeutic agents in thwarting retinal inflammation. "
4.	Graft vs Host Disease (Graft-Versus-Host Disease) 04/01/2009 - "Preventive usage of broad spectrum chemokine inhibitor NR58-3.14.3 reduces the severity of pulmonary and hepatic graft-versus-host disease."
5.	Brain Ischemia (Cerebral Ischemia) 06/01/2001 - "In the current study, the authors investigate the neuroprotective action of NR58-3.14.3, a novel broad-spectrum inhibitor of chemokine function (both CXC and CC types), in a rat model of cerebral ischemia-reperfusion injury. "

Related Drugs and Biologics

1.	Chemokines
2.	Retinaldehyde (Retinal)
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Lipopolysaccharides

Related Therapies and Procedures

1.	Therapeutics