Picrotoxin

A mixture of PICROTOXININ and PICROTIN that is a noncompetitive antagonist at GABA-A receptors acting as a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.

Also Known As:

3,6- Methano- 8H- 1,5,7- trioxacyclopenta(ij)cycloprop(a)azulene- 4,8(3H)- dione, hexahydro- 2a- hydroxy- 9- (1- hydroxy- 1- methylethyl)- 8b- methyl- , (1aR- (1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9S*))- , compd. with (1aR- (1aalpha,2abeta,3beta,6beta,6abeta,8; Cocculin

Pharmalogical Action Categories:

Antidotes
Central Nervous System Stimulants
Convulsants

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - Picrotoxin: 687
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Picrotoxin: 687
- Lactones: 1549
  - Picrotoxin: 687
Complex Mixtures: 1906
- Biological Products
  - Plant Preparations: 622
    - Plant Extracts: 3916
      - Picrotoxin: 687
Biological Factors: 2472
- Biological Toxins: 20
  - Picrotoxin: 687
Pharmaceutical Preparations
- Plant Extracts: 3916
  - Picrotoxin: 687

picrotin

Bio-Agent Context: Research Results