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thonningianin A

an ellagitannin from the African medicinal herb Thonningia sanguinea; structure in first source

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Jiang, Jian-Guo: 1 article (08/2015)
2.	Yang, Li: 1 article (08/2015)
3.	Zhang, Tian-Tian: 1 article (08/2015)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2015 - "The anti-cancer activity of Thonningianin A was confirmed by the characteristic patterns of DNA fragmentation and cell cycle arrest, suggesting that Th A is an effective antitumor ingredient in natural plant foods, and is worthy of further study. " 08/01/2015 - "The anti-cancer activities of Thonningianin A on the HepG-2 human hepatocellular carcinoma cell line were evaluated by MTT assay, flow cytometry, quantitative real-time PCR and western blotting. "
2.	Vascular Calcification 11/15/2023 - "Here, the natural compound thonningianin A (TA) was found to ameliorate vascular calcification in T2DM via the activation of L-type calcium ion channels. " 11/15/2023 - "L-type calcium ion channel-mediated activation of autophagy in vascular smooth muscle cells via thonningianin A (TA) alleviates vascular calcification in type 2 diabetes mellitus."
3.	Hepatocellular Carcinoma (Hepatoma) 08/01/2015 - "Effects of thonningianin A in natural foods on apoptosis and cell cycle arrest of HepG-2 human hepatocellular carcinoma cells." 08/01/2015 - "The anti-cancer activities of Thonningianin A on the HepG-2 human hepatocellular carcinoma cell line were evaluated by MTT assay, flow cytometry, quantitative real-time PCR and western blotting. "
4.	Type 2 Diabetes Mellitus (MODY) 11/15/2023 - "L-type calcium ion channel-mediated activation of autophagy in vascular smooth muscle cells via thonningianin A (TA) alleviates vascular calcification in type 2 diabetes mellitus."
5.	Alzheimer Disease (Alzheimer's Disease) 08/03/2022 - "Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer's disease."

Related Drugs and Biologics

1.	Inflammasomes
2.	Calcium Channels (Calcium Channel)