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1-O-hexadecylpropanediol-3-p-acyclovir

structure in first source

Also Known As:

H-3-acyclovir

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Hypoxanthines: 1
        Guanine: 1793
        Acyclovir: 4814
        1-O-hexadecylpropanediol-3-p-acyclovir: 2

Experts

1.	Beadle, J R: 2 articles (07/2000 - 01/2000)
2.	Hostetler, K Y: 2 articles (07/2000 - 01/2000)
3.	Bellezza, C A: 1 article (07/2000)
4.	Cote, P J: 1 article (07/2000)
5.	Gerin, J L: 1 article (07/2000)
6.	Hornbuckle, W E: 1 article (07/2000)
7.	Korba, B E: 1 article (07/2000)
8.	Tennant, B C: 1 article (07/2000)
9.	Tochkov, I A: 1 article (07/2000)
10.	Aldern, K A: 1 article (01/2000)

Related Diseases

1.	Infections 07/01/2000 - "Oral 1-O-hexadecylpropanediol-3-P-acyclovir appeared to be safe and effective in chronic woodchuck hepatitis virus infection." 01/01/2000 - "We synthesized, 1-O-hexadecylpropanediol-3-P-acyclovir, an orally bioavailable lipid prodrug of acyclovir and evaluated it for in vitro and in vivo activity against herpes simplex virus infections. "
2.	Cytomegalovirus Infections (Inclusion Disease) 01/01/2000 - "In vitro, 1-O-hexadecylpropanediol-3-P-acyclovir was also more active than acyclovir in a thymidine kinase negative mutant strain of HSV-1 (DM21) and had somewhat higher activity in cytomegalovirus infection in vitro due to it's ability to bypass thymidine kinase."

Related Drugs and Biologics

1.	Thymidine Kinase
2.	Prodrugs
3.	Lipids
4.	Acyclovir (Aciclovir)