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crinamine

RN given for (3alpha,5alpha,11R,13beta,19alpha)-isomer; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Ethylamines: 5
    - Phenethylamines: 28
      - Amaryllidaceae Alkaloids: 33
        crinamine: 2
Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Amaryllidaceae Alkaloids: 33
    - crinamine: 2

Experts

1.	Asawapirom, Udom: 1 article (01/2019)
2.	Chaichompoo, Waraluck: 1 article (01/2019)
3.	Iempridee, Tawin: 1 article (01/2019)
4.	Jantimaporn, Angkana: 1 article (01/2019)
5.	Japrung, Deanpen: 1 article (01/2019)
6.	Khongkow, Mattaka: 1 article (01/2019)
7.	Khumkhrong, Phattharachanok: 1 article (01/2019)
8.	Namdee, Katawut: 1 article (01/2019)
9.	Piboonprai, Kitiya: 1 article (01/2019)
10.	Pimtong, Wittaya: 1 article (01/2019)

Related Diseases

1.	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/01/2019 - "In this study, we demonstrate that crinamine was more cytotoxic to cervical cancer cells than normal cells. " 01/01/2019 - "Crinamine Induces Apoptosis and Inhibits Proliferation, Migration, and Angiogenesis in Cervical Cancer SiHa Cells." 01/01/2019 - "Our findings provide a first insight into crinamine's anticancer activity, highlighting its potential use as an alternative bioactive compound for cervical cancer chemoprevention and therapy." 01/01/2019 - "Importantly, crinamine also exerted anti-angiogenic activities by inhibiting secretion of VEGF-A protein in cervical cancer cells and blood vessel development in zebrafish embryos. "
2.	Hypoxia (Hypoxemia) 10/01/2006 - "Crinamine from Crinum asiaticum var. japonicum inhibits hypoxia inducible factor-1 activity but not activity of hypoxia inducible factor-2." 10/01/2006 - "In a search for natural product inhibitors of hypoxia inducible factor-1 (HIF-1) function, crinamine (1), a crinane type alkaloid, showed potent dose dependent inhibition (IC50 = 2.7 microM) of HIF-1alpha in a cell-based reporter gene assay. "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Proteins (Proteins, Gene)
3.	Alkaloids
4.	crinane

Related Therapies and Procedures

1.	Chemoprevention
2.	Therapeutics