imidazoline I1 receptors

a type of imidazoline receptors found in synaptic plasma membranes that binds CLONIDINE (unlike type I2); amino acid sequence in first source

Also Known As:

I1 imidazoline receptors; imidazoline receptor 1; imidazoline-1 receptor; receptor IR1

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Drug Receptors: 61
    - Imidazoline Receptors: 122
      - imidazoline I1 receptors: 9

Experts

1.	Bousquet, Pascal: 4 articles (11/2019 - 07/2006)
2.	Greney, Hugues: 3 articles (11/2019 - 01/2015)
3.	Dali-Youcef, Nassim: 2 articles (11/2019 - 07/2015)
4.	Niederhoffer, Nathalie: 2 articles (11/2019 - 07/2015)
5.	Weiss, Maud: 2 articles (11/2019 - 07/2015)
6.	Feldman, Josiane: 2 articles (01/2015 - 07/2006)
7.	Aubertin, Gaëlle: 1 article (11/2019)
8.	Benameur, Djamil: 1 article (11/2019)
9.	Choquet, Philippe: 1 article (11/2019)
10.	Monassier, Laurent: 1 article (11/2019)

Related Diseases

1.	Bradycardia 07/30/2006 - "This work aimed to study the respective effects of central alpha2-adrenergic receptors (alpha2-ARS) and I1 imidazoline receptors (I1Rs) in the facilitatory effects of imidazoline-like drugs on the reflex bradycardia (RB). "
2.	Metabolic Syndrome (Dysmetabolic Syndrome X) 02/01/2000 - "Agonists of I1 imidazoline receptors are suitable in particular for the treatment of hypertension associated with metabolic syndrome. " 07/15/2015 - "We recently reported that activation of I1 imidazoline receptors (I1R) improves several symptoms of the metabolic syndrome through sympathoinhibition and increases adiponectin plasma levels in a rat model of metabolic syndrome (Fellmann L, Regnault V, Greney H, et al. J Pharmacol Exp Ther 346: 370-380, 2013). " 01/22/2015 - "Synthesis and biological evaluation of 2-aryliminopyrrolidines as selective ligands for I1 imidazoline receptors: discovery of new sympatho-inhibitory hypotensive agents with potential beneficial effects in metabolic syndrome." 11/01/2019 - "We previously observed that selective agonists of the sympatho-inhibitory I1 imidazoline receptors (LNP ligands) have favorable effects on several cardiovascular and metabolic disorders defining the metabolic syndrome, including body weight. "
3.	Ocular Hypotension 01/01/1994 - "5) Imidazoline (I1) receptors, located in the CNS, play a role in MOX- and OXY-induced ocular hypotension, as suggested by the ability of the putative imidazoline (I1) receptor antagonist efaroxan, to inhibit icvt MOX-, icvt OXY- and topical OXY-induced ocular hypotension."
4.	Pain (Aches) 06/01/2005 - "Together, these results indicate that agmatine produces dose-related antinociception in several models of chemical pain through mechanisms that involve an interaction with opioid, serotonergic (i.e., through 5-HT2A and 5-HT3 receptors) and nitrergic systems, as well as via an interaction with alpha2-adrenoceptors and imidazoline I1 receptors."
5.	Insulinoma 09/01/1994 - "The effect on insulin release of efaroxan, an alpha 2-adrenoceptor antagonist and a highly potent drug at imidazoline I1 receptors, and the effects of seven other imidazoline compounds selective for the imidazoline I1 or I2 receptors, were studied in the rat insulinoma cell line RIN-5AH. "

Related Drugs and Biologics

1.	Imidazolines
2.	Ligands
3.	efaroxan
4.	Adiponectin
5.	Insulin (Novolin)
6.	Opioid Analgesics (Opioids)
7.	Agmatine