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leptin (116-130)

Also Known As:

(D-Leu-4)-OB3; LEP-(116-130); OB3 peptide; Ser-Cys-Ser-Leu-Pro-Gln-Thr; seryl-cysteinyl-seryl-leucyl-prolyl-glutaminyl-threonine

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chin, Yu-Tang: 3 articles (07/2017 - 05/2016)
2.	Davis, Paul J: 3 articles (07/2017 - 05/2016)
3.	Fu, Earl: 3 articles (07/2017 - 05/2016)
4.	Hsieh, Meng-Ti: 3 articles (07/2017 - 05/2016)
5.	Lin, Hung-Yun: 3 articles (07/2017 - 05/2016)
6.	Tang, Heng-Yuan: 3 articles (07/2017 - 05/2016)
7.	Chang, Heng-Yu: 2 articles (01/2017 - 05/2016)
8.	Crawford, Dana R: 2 articles (01/2017 - 05/2016)
9.	Grasso, Patricia: 2 articles (01/2017 - 05/2016)
10.	Ke, Chien-Chih: 2 articles (01/2017 - 05/2016)

Related Diseases

1.	Thyroid Neoplasms (Thyroid Cancer) 01/01/2017 - "Correction: Novel leptin OB3 peptide-induced signaling and progression in thyroid cancers: Comparison with leptin." 05/10/2016 - "Novel leptin OB3 peptide-induced signaling and progression in thyroid cancers: Comparison with leptin."
2.	Body Weight (Weight, Body) 11/01/1999 - "In homozygous female C57BLKS/J-m db/db mice that do not express OB-Rb, intraperitoneal administration of LEP-(116-130) reduced body weight gain and blood glucose levels but not food intake, which further supports a mechanism of action that does not require peptide interaction with OB-Rb." 07/01/2000 - "We have previously reported that a synthetic peptide amide corresponding to amino acid residues 116-130 of mouse leptin, LEP-(116-130), reduces body weight gain, food intake, and blood glucose levels in ob/ob and db/db mice. "
3.	Ovarian Neoplasms (Ovarian Cancer) 07/27/2017 - "In summary, our findings suggest that the OB3 peptide may prevent leptin-induced ovarian cancer initiation and progression by disrupting leptin-induced proliferative signals via STAT3 phosphorylation and ERα activation. " 07/27/2017 - "Leptin OB3 peptide suppresses leptin-induced signaling and progression in ovarian cancer cells."
4.	Neoplasms (Cancer) 07/27/2017 - "Therefore, the OB3 peptide is a potential anticancer agent that might be employed to prevent leptin-induced cancers in obese people." 07/27/2017 - "The OB3 peptide, a synthetic peptide, was shown to be more active than leptin in regulating metabolism but with no mitogenic effects in cancer cells. "
5.	Atrophy 05/01/2000 - "Leptin[1-147] and leptin[116-130] caused a significant adrenal atrophy, which was mainly due to the decrease in the volume of zona fasciculata (ZF) and in the number of its parenchymal cells. "

Related Drugs and Biologics

1.	Leptin
2.	Peptides (Polypeptides)
3.	Blood Glucose (Blood Sugar)
4.	Antineoplastic Agents (Antineoplastics)
5.	Amino Acids
6.	Amides