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PA 824

nitroimidazopyran derived from 5-nitroimidazoles; a prodrug that requires activation by a bacterial F420-depedent glucose-6-phosphate dehydrogenase (Fgd) and nitroreductase to activate components that then inhibit bacterial mycolic acid and protein synthesis; structure in first source
Also Known As:
PA-824; PA824
Networked: 46 relevant articles (4 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Barry, Clifton E: 7 articles (01/2014 - 01/2006)
2. Manjunatha, Ujjini H: 5 articles (01/2014 - 01/2006)
3. Dowd, Cynthia S: 5 articles (01/2012 - 01/2006)
4. Tyagi, Sandeep: 5 articles (01/2011 - 06/2005)
5. Dawson, Rodney: 4 articles (05/2015 - 08/2010)
6. Tasneen, Rokeya: 4 articles (01/2015 - 04/2008)
7. Peloquin, Charles A: 4 articles (12/2011 - 08/2006)
8. Diacon, Andreas H: 3 articles (05/2015 - 08/2010)
9. van Niekerk, Christo: 3 articles (05/2015 - 08/2010)
10. Venter, Amour: 3 articles (05/2015 - 08/2010)

Related Diseases

1. Tuberculosis (Tuberculoses)
2. Infection
3. Latent Tuberculosis
4. Body Weight (Weight, Body)
5. Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis)

Related Drugs and Biologics

1. Isoniazid (Ftivazide)
2. Rifampin (Rifampicin)
3. diphenyl (biphenyl)
4. moxifloxacin (Avelox)
5. Lecithins
6. Methylcellulose (BFL)
7. Pyrazinamide
8. Nitroimidazoles
9. Drug Combinations
10. Aerosols

Related Therapies and Procedures

1. Therapeutics
2. Combination Drug Therapy (Combination Chemotherapy)