|1.||Heikkila, John J: 4 articles (04/2011 - 11/2007)|
|2.||Yokota, S: 3 articles (08/2004 - 06/2000)|
|3.||Ryozawa, Shomei: 2 articles (06/2012 - 01/2011)|
|4.||Kuramitsu, Yasuhiro: 2 articles (06/2012 - 01/2011)|
|5.||Sakaida, Isao: 2 articles (06/2012 - 01/2011)|
|6.||Taba, Kumiko: 2 articles (06/2012 - 01/2011)|
|7.||Nakamura, Kazuyuki: 2 articles (06/2012 - 01/2011)|
|8.||Yokota, Shinichi: 2 articles (12/2006 - 08/2006)|
|9.||Delaney, Angela: 1 article (07/2015)|
|10.||Hawdon, John M: 1 article (07/2015)|
01/01/2001 - "The inhibition of thermotolerance by KNK437 may help to improve the efficacy of clinical fractionated hyperthermia."
09/01/2005 - "Attenuation of chronic thermotolerance by KNK437, a benzylidene lactam compound, enhances thermal radiosensitization in mild temperature hyperthermia combined with low dose-rate irradiation."
01/01/2001 - "Hsp72 were synthesized 8 h after hyperthermia at 44 degrees C for 10 min, and their synthesis was inhibited by administration of KNK437 6 h before hyperthermia. "
01/01/2011 - "KNK437, a benzylidene lactam compound, sensitises prostate cancer cells to the apoptotic effect of hyperthermia."
01/01/2011 - "KNK437 and quercetin pretreatment enhanced the apoptotic effect of hyperthermia in both cells. "
|2.||Pancreatic Neoplasms (Pancreatic Cancer)
01/01/2011 - "This report describes the benefits of a treatment strategy combining the HSP inhibitor KNK437 with GEM for GEM-resistant pancreatic cancer cells. "
06/01/2012 - "Furthermore, it has been shown that treatment strategies combining the HSP inhibitor KNK437 or interferon-γ (IFN-γ) with gemcitabine, were effective in gemcitabine-resistant pancreatic cancer cells in vitro. "
01/01/2011 - "KNK437 downregulates heat shock protein 27 of pancreatic cancer cells and enhances the cytotoxic effect of gemcitabine."
10/01/2008 - "In this study, we compared the effect of KNK437 (N-formyl-3, 4-methylenedioxy-benzylidene-gamma-butyrolactam), a benzylidene lactam compound, on heat shock and chemical stressor-induced hsp30 gene expression in Xenopus laevis A6 kidney epithelial cells. "
04/01/2011 - "This phenomenon was controlled at the transcriptional level since pre-treatment of cells with KNK437, a heat shock factor 1 (HSF1) inhibitor, repressed HSP accumulation. "
10/01/2010 - "Transcriptional inhibition of HSP70 expression by a specific heat shock transcript factor inhibitor, KNK437, reduced the serum level, and the re-distribution of HSP70. "
05/01/2010 - "The activation of heat shock factor 1 (HSF1) may be involved in MG132-induced hsp gene expression in A6 cells since KNK437, a HSF1 inhibitor, repressed the accumulation of HSP30 and HSP70. "
10/01/2008 - "These results show that KNK437 is effective at inhibiting both heat shock- and chemical stress-induced hsp gene expression in amphibian cells."
05/11/2012 - "Treatment of human cancer cells MDA-MB-231 and T98G with KNK437 sensitized them to ionizing radiation (IR). "
01/01/2001 - "At a concentration of 200 mg/kg, KNK437 alone showed no antitumor effects and did not increase the thermosensitivity of nontolerant tumors. "
01/01/2001 - "The concentration of KNK437 in the tumors gradually increased and reached a peak 6 h after i.p. "
01/01/2001 - "The concentrations of KNK437 in the tumors and the sera of the mice were examined by high-performance liquid chromatography. "
05/11/2012 - "We hypothesized that KNK437 sensitizes cancer cells to radiation and overrides hypoxia-induced radioresistance via destabilizing HIF-1α. "
|5.||Squamous Cell Carcinoma (Epidermoid Carcinoma)
12/01/2006 - "Effects of KNK437 on heat-induced methylation of histone H3 in human oral squamous cell carcinoma cells."
08/01/2006 - "KNK437 induced the resistance of A-172 cells and human squamous cell carcinoma cells (SAS) to X-rays. "
08/01/2004 - "Effects of a heat shock protein inhibitor KNK437 on heat sensitivity and heat tolerance in human squamous cell carcinoma cell lines differing in p53 status."
|3.||Heat-Shock Proteins (Heat-Shock Protein)
|4.||Messenger RNA (mRNA)
|7.||dasatinib (BMS 354825)
|8.||sorafenib (BAY 43-9006)
|9.||D 21266 (perifosine)
|10.||DNA (Deoxyribonucleic Acid)