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L 685458

a gamma-secretase inhibitor; structure in first source
Also Known As:
1-benzyl-4-(1-(1-carbamoyl-2-phenylethylcarbamoyl-3-methylbutylcarbamoyl)-2-hydroxy-5-phenylpentyl)carbamic acid tert-butyl ester; GSI-X cpd; L 685,458; L-685,458; L-685458
Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Giaretti, Walter: 1 article (11/2009)
2. Biollo, Emanuela: 1 article (11/2009)
3. Monticone, Massimiliano: 1 article (11/2009)
4. Castagnola, Patrizio: 1 article (11/2009)
5. Melotti, Alice: 1 article (11/2009)
6. Fabbi, Marina: 1 article (11/2009)
7. Romeo, Francesco: 1 article (11/2009)
8. Fabiano, Andrea: 1 article (11/2009)
9. Maffei, Massimo: 1 article (11/2009)
10. Corte, Giorgio: 1 article (11/2009)

Related Diseases

1. Breast Neoplasms (Breast Cancer)
2. Tics (Tic)
3. B-Cell Leukemia (Leukemia, B Cell)
4. Neuroblastoma
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Proteasome Endopeptidase Complex (Proteasome)
2. lactacystin
3. 2'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))
4. benzyloxycarbonyl- leucyl- leucyl- norleucinal
5. bortezomib (Velcade)
6. benzyloxycarbonylleucyl-leucyl-leucine aldehyde
7. Amyloid Precursor Protein Secretases (beta-Secretase)
8. Caspase 3 (Caspase-3)
9. Cyclin D1
10. NF-kappa B (NF-kB)