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constitutive androstane receptor

RefSeq NM_005122 (human); NM_009803 (mouse); NM_022941 (rat)
Also Known As:
CAR nuclear receptor; CAR orphan nuclear receptor; NR1I3 protein, human; Nr1i3 protein, mouse; Nr1i3 protein, rat; constitutive active receptor; constitutive androstane receptor beta; constitutive androstane receptor, human; constitutive androstane receptor, mouse; constitutive androstane receptor, rat; hCAR protein, human; nuclear receptor subfamily 1, group I, member 3, human; nuclear receptor subfamily 1, group I, member 3, mouse; nuclear receptor subfamily 1, group I, member 3, rat
Networked: 79 relevant articles (4 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Inoue, Kaoru: 5 articles (09/2015 - 01/2013)
2. Yoshida, Midori: 5 articles (09/2015 - 01/2013)
3. Kodama, Yukio: 5 articles (09/2015 - 01/2013)
4. Takahashi, Miwa: 5 articles (09/2015 - 01/2013)
5. Moore, David D: 5 articles (10/2011 - 06/2005)
6. Lake, Brian G: 4 articles (06/2015 - 01/2009)
7. Huang, Wendong: 4 articles (10/2008 - 06/2005)
8. Tamura, Kei: 3 articles (04/2015 - 07/2013)
9. Ozawa, Shogo: 3 articles (04/2015 - 01/2013)
10. Wang, Hongbing: 3 articles (08/2014 - 01/2013)

Related Diseases

1. Asthma (Bronchial Asthma)
01/01/2013 - "Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma.  However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by CYP3A enzymes in the lung.  CYP3A4, 3A5, and 3A7 enzymes metabolize glucocorticoids, which in turn induce CYP3A genes.  However, the mechanism of CYP3A5 mRNA regulation by glucocorticoids in lung cells has not been determined.  In hepatocytes, glucocorticoids bind to the glucocorticoid receptor (GR), which induces the expression of the constitutive androstane receptor or pregnane X receptor; both of which bind to the retinoid X receptor alpha, leading to the induction of CYP3A4, 3A5, and 3A7.  There is also evidence to suggest a direct induction of CYP3A5 by GR activation in liver cells. "
01/01/2013 - "Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma.  However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by CYP3A enzymes in the lung.  CYP3A4, 3A5, and 3A7 enzymes metabolize glucocorticoids, which in turn induce CYP3A genes.  However, the mechanism of CYP3A5 mRNA regulation by glucocorticoids in lung cells has not been determined.  In hepatocytes, glucocorticoids bind to the glucocorticoid receptor (GR), which induces the expression of the constitutive androstane receptor or pregnane X receptor; both of which bind to the retinoid X receptor alpha, leading to the induction of CYP3A4, 3A5, and 3A7.  There is also evidence to suggest a direct induction of CYP3A5 by GR activation in liver cells. "
2. Neoplasms (Cancer)
3. Pre-Eclampsia (Preeclampsia)
4. Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
5. Hepatocellular Carcinoma (Hepatoma)
09/01/2011 - "Xenobiotic agonists of the constitutive androstane receptor (CAR) induce massive acute hyperplasia of mouse liver and facilitate the outgrowth of hepatocellular carcinomas with activated β-catenin. "
06/01/2011 - "The purpose of this study was to determine whether in non-genetically modified mice (1) the Hippo pathway is involved in the regulation of adaptive liver enlargement caused by the mitogen 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), an agonist of constitutive androstane receptor and (2) a dysregulation of this pathway occurs during the development of chemically induced hepatocellular carcinoma (HCC). "
09/10/2010 - "Here we demonstrate that by combining adenoviral vectors for CCAAT/enhancer-binding protein alpha (C/EBPalpha), hepatocyte nuclear factor 4alpha (HNF4alpha), and constitutive androstane receptor, the CYP2B6 expression and inducibility by CITCO are restored in human hepatoma HepG2 cells at levels similar to those in cultured human hepatocytes. "
09/01/2001 - "Here we report experiments in the chicken hepatoma cell line LMH that suggest evolutionary conservation of the signaling pathways triggered by pregnane X receptor, constitutive androstane receptor, and chicken xenobiotic receptor. "
05/20/2007 - "Moreover contrary to other human hepatoma cell lines including HepG2 cells, HepaRG cells express various CYPs (CYP1A2, 2B6, 2C9, 2E1, 3A4) and the nuclear receptors constitutive androstane receptor (CAR) and pregnane X receptor (PXR) at levels comparable to those found in cultured primary human hepatocytes. "

Related Drugs and Biologics

1. pregnane X receptor
2. Messenger RNA (mRNA)
3. Cytochrome P-450 CYP3A
4. Enzymes
5. Retinoid X Receptor alpha
6. Glucocorticoid Receptors (Glucocorticoid Receptor)
7. Glucocorticoids
8. Ligands
9. Paclitaxel (Taxol)
10. Cytoplasmic and Nuclear Receptors (Nuclear Receptors)

Related Therapies and Procedures

1. Hepatectomy