oregonin

a diarylheptanoid from the bark of Alnus hirsuta var. sibirica; inhibits cyclooxygenase-2 expression; structure in first source

Also Known As:

(5S)-1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-beta-D-xylopyranoside; 1,7-Bis(3,4-dihydroxyphenyl)-5-hydroxy-3-heptanone

Networked: 15 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Diarylheptanoids: 471
        oregonin: 15
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Heptanes: 70
        Diarylheptanoids: 471
        oregonin: 15

Experts

1.	Lee, Min Won: 5 articles (04/2012 - 12/2002)
2.	Shoyama, Yukihiro: 3 articles (01/2015 - 01/2014)
3.	Tung, Nguyen Huu: 3 articles (01/2015 - 01/2014)
4.	Choi, Young Wook: 3 articles (12/2013 - 01/2010)
5.	Choi, Sun Eun: 3 articles (08/2010 - 10/2008)
6.	Krasilnikova, Jelena: 2 articles (12/2018 - 03/2015)
7.	Telysheva, Galina: 2 articles (12/2018 - 03/2015)
8.	Edoh, Dominic: 2 articles (01/2015 - 01/2014)
9.	Morinaga, Osamu: 2 articles (01/2015 - 01/2014)
10.	Uto, Takuhiro: 2 articles (01/2015 - 01/2014)

Related Diseases

1.	Alopecia (Baldness) 01/01/2021 - "The aims of this study are determining the efficacy of various biomarkers related to hair loss, evaluated by extracting the branch with 60% alcohol, and purely separating diarylheptanoid oregonin, an indicator and active substance, from 60% alcohol extract of the tree. " 01/01/2021 - "Moreover, we examined the ameliorative effects of 60% alcohol extract of the tree and oregonin against changes of oxidative stress-induced cytokine and testosterone-induced dihydrotestosterone production as crucial pathways of the hair loss mechanism. "
2.	Melanoma (Melanoma, Malignant) 12/01/2013 - "Efficacy of oregonin investigated by non-invasive evaluation in a B16 mouse melanoma model." 08/01/2002 - "Enhancement of NK cytotoxicity, antimetastasis and elongation effect of survival time in B16-F10 melanoma cells by oregonin." 12/01/2013 - "Treatment doses of oregonin were administered three times weekly, for 30 days from the 11th day after transplantation of the melanoma cells, in each group. " 08/01/2002 - "Moreover, oregonin significantly reduced the incidence of pulmonary metastasis, which may be developed from B16-F10 melanoma cells. "
3.	Atopic Dermatitis (Atopic Eczema) 01/01/2010 - "Facilitated skin permeation of oregonin by elastic liposomal formulations and suppression of atopic dermatitis in NC/Nga mice." 08/01/2010 - "Effect of topical application and intraperitoneal injection of oregonin on atopic dermatitis in NC/Nga mice." 01/01/2010 - "To develop an external preparation of oregonin (ORG) for the treatment of atopic dermatitis (AD), conventional creams (CC) and elastic liposomes (EL) containing ORG have been formulated and examined for their in vitro skin permeation properties and in vivo therapeutic efficacy assessments. "
4.	Inflammation (Inflammations) 06/01/2018 - "The findings of this study suggest that oregonin is a potential candidate for treatment of IBD by preventing mucosal inflammation and barrier disruption." 06/01/2018 - "Oregonin inhibits inflammation and protects against barrier disruption in intestinal epithelial cells." 06/01/2018 - "Oregonin, a major diarylheptanoid derivative isolated from Alnus japonica, exerts anti-inflammatory effects; however, little is known about the effect of oregonin in intestinal inflammation. " 03/13/2015 - "Additionally, we observed that treatment of lipopolysaccharide-exposed macrophages with oregonin significantly induced the expression of antioxidant-related genes, including Heme oxygenase-1 and NADPH dehydrogenase quinone 1. In summary, we have shown that oregonin reduces lipid accumulation, inflammation and ROS production in primary human macrophages, indicating that oregonin has anti-inflammatory bioactivities. "
5.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 06/01/2018 - "The current study investigated the potential of oregonin for clinical applications in the treatment of inflammatory bowel disease (IBD) and elucidated its underlying molecular mechanisms. "

Related Drugs and Biologics

1.	Diarylheptanoids
2.	Biomarkers (Surrogate Marker)
3.	Indicators and Reagents (Reagents)
4.	Liposomes (Liposome)
5.	Antioxidants
6.	Heptanes
7.	hirsutenone
8.	hirsutanone
9.	hirsutanonol
10.	Heme Oxygenase-1

Related Therapies and Procedures

1.	Transplantation
2.	Intraperitoneal Injections