|1.||Fenical, W: 1 article (02/2000)|
|2.||Epifanio, R A: 1 article (02/2000)|
|3.||Vervoort, H: 1 article (02/2000)|
10/21/1999 - "[formula: see text] Tamandarin A (1), a newly isolated natural product similar in structure to didemnin B (2), was shown to be somewhat more active in vitro than 2 against pancreatic carcinoma with an ED50 value 1.5 to 2 ng/mL. We report here the first total synthesis of 1. The key steps include a practical stereoselective synthesis of the Hiv-isostatine unit, high-yielding linear precursor formation, a successful macrocyclization, and coupling of the macrocycle with the side chain to afford tamandarin A (1)."