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tamandarin A
Also Known As:
2-Hiv-didemnin B; didemnin B, Hiv(2)-; didemnin B, alpha-hydroxyisovaleryl(2)-; tamandarin-A
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Macrocyclic Compounds: 15
Cyclic Peptides: 530
Depsipeptides: 297
tamandarin A: 2
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Cyclic Peptides: 530
Depsipeptides: 297
tamandarin A: 2
Experts
1.
Epifanio, R A
: 1 article (02/2000)
2.
Fenical, W
: 1 article (02/2000)
3.
Vervoort, H
: 1 article (02/2000)
Related Diseases
1.
Pancreatic Neoplasms (Pancreatic Cancer)
10/21/1999 - "
[formula: see text] Tamandarin A (1), a newly isolated natural product similar in structure to didemnin B (2), was shown to be somewhat more active in vitro than 2 against pancreatic carcinoma with an ED50 value 1.5 to 2 ng/mL. We report here the first total synthesis of 1. The key steps include a practical stereoselective synthesis of the Hiv-isostatine unit, high-yielding linear precursor formation, a successful macrocyclization, and coupling of the macrocycle with the side chain to afford tamandarin A (1).
"
2.
Neoplasms (Cancer)
02/11/2000 - "
The cytotoxicity of tamandarin A (1) was evaluated against various human cancer cell lines and shown to be slightly more potent than didemnin B.
"
Related Drugs and Biologics
1.
didemnins