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PDZ-binding kinase

a mitotic kinase that binds the PDZ2 domain of human Dlg protein (hDlg); phosphorylated during mitosis; found to increase highly in proliferative malignant cells, upregulated in Burkitt's lymphom and during normal fetal development; amino acid sequence in first source; GenBank AF189722
Also Known As:
MAPKK-like protein kinase; Nori-3 protein, human; PBK enzyme; PBK protein, human; PDZ binding kinase, human; T-LAK cell-originated protein kinase, human; TOPK protein, human; lymphokine-activated killer T-cell-originated protein kinase, human; spermatogenesis-related protein kinase
Networked: 63 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Sung, Wen-Wei: 3 articles (04/2021 - 06/2016)
2. Wang, Zhe: 3 articles (04/2016 - 12/2006)
3. Lei, Bin: 3 articles (02/2015 - 11/2013)
4. Liu, Shuguang: 3 articles (02/2015 - 11/2013)
5. Shen, Hong: 3 articles (02/2015 - 11/2013)
6. Rapoport, Aaron P: 3 articles (06/2007 - 01/2004)
7. Kong, Beihua: 2 articles (01/2021 - 01/2019)
8. Li, Rongrong: 2 articles (01/2021 - 01/2019)
9. Li, Yingwei: 2 articles (01/2021 - 01/2019)
10. Ma, Hanlin: 2 articles (01/2021 - 01/2019)

Related Diseases

1. Neoplasms (Cancer)
2. Breast Neoplasms (Breast Cancer)
02/01/2016 - "Transcriptomic analyses identify association between mitotic kinases, PDZ-binding kinase and BUB1, and clinical outcome in breast cancer."
01/01/2016 - "The overexpression of PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK) has been associated with hematologic tumors, breast cancer and various other cancers. "
09/28/2022 - "PDZ-binding kinase/T-lymphokine-activated killer cell-derived protein kinase (PBK/TOPK) is a potential prognostic indicator for patients with breast cancer. "
09/15/2006 - "PDZ-binding kinase/T-LAK cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast cancer."
09/15/2023 - "As a result, 10 Hub genes closely associated with early diagnosis of breast cancer were identified: PDZ-binding kinase, cell cycle protein A2, cell division cycle-associated protein 8, maternal embryonic leucine zipper kinase, nucleolar and spindle-associated protein 1, BIRC5, cell cycle protein B2, hyaluronan-mediated motility receptor, mitotic arrest deficient 2-like 1, and protein regulator of cytokinesis 1. The findings of this study unveiled the significant involvement of the identified 10 Hub genes in facilitating the growth and proliferation of cancer cells, particularly cell cycle protein A2, cell division cycle-associated protein 8, maternal embryonic leucine zipper kinase, nucleolar and spindle-associated protein 1, hyaluronan-mediated motility receptor, and protein regulator of cytokinesis 1, which demonstrated a more pronounced connection with the onset and progression of breast cancer. "
3. Prolactinoma (Prolactinomas)
4. Leukemia
5. Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)

Related Drugs and Biologics

1. Phenobarbital (Luminal)
2. Protein Kinases (Protein Kinase)
3. Proteins (Proteins, Gene)
4. Phosphotransferases (Kinase)
5. Prolactin
6. Gossypol
7. hyaluronan-mediated motility receptor
8. Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)
9. Type II DNA Topoisomerases (Topoisomerase II)
10. CDC2 Protein Kinase (Protein p34cdc2)

Related Therapies and Procedures

1. Precision Medicine
2. Radiotherapy