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osteoclast stimulating factor

an intracellular protein produced by osteoclast is an SH3-domain containing protein; may be involved in Cbl and Src-mediated pathways; has been sequenced

Also Known As:

OSTF1

Networked: 15 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - osteoclast stimulating factor: 15
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - osteoclast stimulating factor: 15

Experts

1.	Abou-Saleh, Haissam: 1 article (11/2019)
2.	Halade, Ganesh V: 1 article (11/2019)
3.	Ouhtit, Allal: 1 article (11/2019)
4.	Rahman, Md Mizanur: 1 article (11/2019)
5.	Benedetti, Irene: 1 article (01/2019)
6.	Bergonzi, Manuela: 1 article (01/2019)
7.	Brondino, Natascia: 1 article (01/2019)
8.	Cheng, Cheng: 1 article (01/2019)
9.	Corazza, Gino R: 1 article (01/2019)
10.	De Amici, Mara: 1 article (01/2019)

Related Diseases

1.	Bone Resorption 01/01/2019 - "Among these 11 genes, three genes (OSTF1, ADRB1 and NEO1) were speculated to serve roles in PMOP by regulating the balance between bone formation and bone resorption, while two genes (GPR87 and GPR116) may be involved in PMOP by regulating the nuclear factor‑κB signaling pathway. " 06/01/2012 - "No coordinated directional changes were detected for genes involved in bone resorption, although some genes responsible for osteoclast formation and differentiation (Ostf1, Rab9a, and c-Fos) were significantly underexpressed in bone of hibernating bears. " 01/01/2005 - "Osteoclast-stimulating factor increases osteoclast formation and bone resorption through a cellular signal transduction cascade, possibly by its interaction with c-Src or related family members. " 11/08/2019 - "BMD loss protection by CFO was accompanied by reduced levels of the bone resorption marker, TRAP, and the osteoclast-stimulating-factor, RANKL, without affecting the decoy-receptor of RANKL, osteoprotegerin (OPG). " 08/01/2016 - "Human osteoclast-stimulating factor (hOSF) is an intracellular protein produced by osteoclasts that induces osteoclast formation and bone resorption. "
2.	Periodontal Diseases (Periodontal Disease) 08/01/2015 - "A disintegrin and metalloproteinase 8 (ADAM8) is a marker belonging to the class of ADAM family of metalloproteinase which is found to be involved in inflammation and bone resorption in periodontal disease by acting as osteoclast stimulating factor. "
3.	Neoplasms (Cancer) 01/01/2017 - "Depending on the tumor cell type, knockdown of TNFAIP8 was found to be associated with increased mRNA expression of several antiproliferative and apoptotic genes (e.g., IL-24, FAT3, LPHN2, EPHA3) and fatty acid oxidation gene ACADL, and decreased mRNA levels of oncogenes (e.g., NFAT5, MALAT1, MET, FOXA1, KRAS, S100P, OSTF1) and glutamate transporter gene SLC1A1. "
4.	Neoplasm Metastasis (Metastasis) 03/01/2008 - "Macrophage inflammatory protein-1 delta: a novel osteoclast stimulating factor secreted by renal cell carcinoma bone metastasis."
5.	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 11/02/2001 - "Osteoclast-stimulating factor interacts with the spinal muscular atrophy gene product to stimulate osteoclast formation."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Osteoprotegerin
3.	Metalloproteases (Metalloproteinases)
4.	Amino Acid Transport System X-AG (Glutamate Transporter)
5.	Collagen Type I (Type I Collagen)
6.	Disintegrins
7.	Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)
8.	Brain-Derived Neurotrophic Factor (BDNF)
9.	NF-kappa B (NF-kB)
10.	Vitamin D