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phorboxazole A

structure in first source

Also Known As:

phorboxazole B

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - phorboxazole A: 3
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - phorboxazole A: 3

Experts

1.	Meis, Regina M: 2 articles (02/2008 - 02/2006)
2.	Pettit, George R: 2 articles (02/2008 - 02/2006)
3.	Razler, Thomas M: 2 articles (02/2008 - 02/2006)
4.	Smith, Amos B: 2 articles (02/2008 - 02/2006)
5.	Uckun, F M: 1 article (11/2001)

Related Diseases

1.	Neoplasms (Cancer) 02/16/2006 - "Reevaluation of (+)-C(45-46) E-chloroalkenyl phorboxazole A (6) confirms subnanomolar activity across a broad panel of human cancer cell lines." 02/15/2008 - "Specifically, the C(45-46) alkyne, alkene, and alkane phorboxazole A analogues [(+)-4-(+)-6] were constructed and found to display single digit nanomolar cell growth inhibitory activities in a series of human cancer cell lines. "
2.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 11/01/2001 - "In standard MTT assays, synthetic phorboxazole A exhibited potent cytotoxicity against NALM-6 acute lymphoblastic leukemia cells (IC50 = 1.7 nM), BT-20 breast cancer cells (IC50 = 3.4 nM), and U373 glioblastoma cells (IC50 = 6.7 nM). "
3.	Glioblastoma (Glioblastoma Multiforme) 11/01/2001 - "In standard MTT assays, synthetic phorboxazole A exhibited potent cytotoxicity against NALM-6 acute lymphoblastic leukemia cells (IC50 = 1.7 nM), BT-20 breast cancer cells (IC50 = 3.4 nM), and U373 glioblastoma cells (IC50 = 6.7 nM). "
4.	Breast Neoplasms (Breast Cancer) 11/01/2001 - "In standard MTT assays, synthetic phorboxazole A exhibited potent cytotoxicity against NALM-6 acute lymphoblastic leukemia cells (IC50 = 1.7 nM), BT-20 breast cancer cells (IC50 = 3.4 nM), and U373 glioblastoma cells (IC50 = 6.7 nM). "

Related Drugs and Biologics

1.	Alkynes (Acetylenes)
2.	Alkenes (Olefins)
3.	Alkanes