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DZ 3358
structure in first source
Also Known As:
1-(5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl)-3-(4-(3-chlorophenyl)-1-piperazinyl)-1-trans-propene hydrochloride; DZ-3358; DZ3358
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Pyrazoles: 61
DZ 3358: 1
Pyrimidines: 510
DZ 3358: 1
Experts
1.
Ejima, A
: 1 article (03/2000)
2.
Iwahana, M
: 1 article (03/2000)
3.
Ochi, Y
: 1 article (03/2000)
Related Diseases
1.
Stomach Neoplasms (Stomach Cancer)
03/01/2000 - "
Furthermore, using immunofluorescence techniques, we observed microtubule formation in NUGC-3 human gastric cancer cells treated with DZ-3358.
"
2.
Neoplasms (Cancer)
03/01/2000 - "
DZ-3358 may be useful as a new type of tubulin inhibitor and anti-cancer drug.
"
03/01/2000 - "
The differential pattern of growth inhibitory concentrations of DZ-3358 against a series of cancer cell lines was compared with that of colchicine and vincristine, and no correlation was found with the pattern of these two drugs.
"
3.
Leukemia
03/01/2000 - "
DZ-3358 induced the mitotic arrest of P388 murine leukemia cells at 0.4 microgram/ml in a time-dependent manner, and inhibited porcine tubulin polymerization.
"
Related Drugs and Biologics
1.
Tubulin Modulators
2.
Vincristine (Oncovin)
3.
Tubulin
4.
Colchicine