Endo180

an endocytic recycling glycoprotein related to the macrophage mannose receptor expressed on fibroblasts, endothelial cells and macrophages; functions as a lectin receptor; amino acid sequence in first source

Networked: 35 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Behrendt, Niels: 7 articles (07/2017 - 06/2005)
2.	Sturge, Justin: 7 articles (03/2016 - 11/2007)
3.	Isacke, Clare M: 6 articles (01/2022 - 04/2002)
4.	Engelholm, Lars H: 6 articles (01/2016 - 06/2005)
5.	Waxman, Jonathan: 5 articles (02/2016 - 03/2009)
6.	Bugge, Thomas H: 5 articles (01/2016 - 06/2005)
7.	Madsen, Daniel H: 5 articles (01/2016 - 04/2007)
8.	Gronau, Julian H: 4 articles (02/2016 - 04/2012)
9.	Rodriguez-Teja, Mercedes: 4 articles (02/2016 - 04/2012)
10.	Iravani, Marjan: 3 articles (01/2022 - 03/2010)

Related Diseases

1.	Osteosarcoma (Osteogenic Sarcoma) 01/01/2016 - "This points to uPARAP/Endo180 as a promising therapeutic target in osteosarcoma, with particular prospects for improved neoadjuvant therapy." 03/01/2016 - "For the first time they have demonstrated that a mouse monoclonal antibody targeting the collagen receptor Endo180 (CD280, MRC2 uPARAP) can prevent osteolysis and bone destruction in a syngeneic model of advanced osteosarcoma. "
2.	Hypertension (High Blood Pressure) 03/01/2020 - "Surprisingly, whether H2S ameliorates receptor-mediated (urokinase plasminogen activator receptor-associated protein, uPARAP/Endo180) collagen dysregulation in Ang-II hypertension is not clear. "
3.	Neoplasms (Cancer) 01/01/2022 - "The addition of wild-type, but not Endo180-deficient, CAFs in coimplantation studies restricted CD8+ T-cell intratumoral infiltration, and tumors in Endo180 knockout mice exhibited increased CD8+ T-cell infiltration and enhanced sensitivity to ICB compared with tumors in wild-type mice. " 01/01/2022 - "The CAF receptor Endo180 (Mrc2) is predominantly expressed on myofibroblastic CAFs, and its genetic deletion depleted a subset of αSMA-expressing CAFs and impaired tumor progression in vivo. " 10/01/2015 - "With a particular focus on matrix turnover in cancer, this review presents the necessary background for understanding the function of uPARAP/Endo180 at the molecular and cellular level, followed by an in-depth survey of the available knowledge of the expression and role of this receptor in various types of cancer and other degenerative diseases." 10/01/2015 - "Important pathological functions of uPARAP/Endo180 have been identified in various cancers and in several fibrotic conditions. " 11/01/2007 - "Second, a proportion of Endo180(+) tumors were shown to have Endo180 gene copy number gains and amplifications. "
4.	Prostatic Neoplasms (Prostate Cancer) 03/01/2015 - "This study identifies the interaction between CTLD4 in Endo180 and CD147 as an EMT suppressor and indicates that stabilization of this molecular complex improves prostate cancer survival rates." 03/01/2015 - "This study provides a rationale for targeting CTLD2 in Endo180 in prostate cancer and other pathologies in which increased basal lamina thickness and tissue stiffness are driving factors. " 02/01/2016 - "The concomitant decrease in PC3 cell migration and increase in Endo180 expression induced by stromal LOX inhibition indicates that the Endo180-dependent rounded mode of prostate cancer cell migration requires ECM crosslinking. " 02/01/2016 - "Human osteoblast-derived and fibroblast-derived ECM supported a rounded 'amoeboid-like' mode of cell migration and enhanced Endo180 expression in three prostate cancer cell lines (PC3, VCaP, DU145). " 03/01/2015 - "AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival."
5.	Neoplasm Metastasis (Metastasis) 10/01/2021 - "Here we show that genetic deletion of the Endo180 (MRC2) receptor, predominantly expressed by a population of matrix-remodelling CAFs, profoundly limits tumour growth and metastasis; effects that can be recapitulated in 3D co-culture assays. " 04/01/2012 - "Immunohistochemical analysis of core biopsies from bone metastasis revealed higher levels of Endo180 expression in tumour cell foci than cells in the surrounding stroma. " 01/15/2013 - "Here, we confirm the release and diagnostic accuracy of soluble Endo180 for diagnosing metastasis in breast cancer (BCa). " 04/01/2012 - "The findings of this study provide a rationale for targeting collagen remodelling by Endo180 in bone metastases and other collagen matrix pathologies." 01/15/2013 - "Bisphosphonate treatment was associated with reduced Endo180 levels in BCa patients with bone metastasis (P=0.011; n=42). "

Related Drugs and Biologics

1.	Collagen
2.	Urokinase Plasminogen Activator Receptors
3.	Proteins (Proteins, Gene)
4.	Transforming Growth Factor beta1 (TGF beta 1)
5.	Fibrillar Collagens
6.	Interleukin-6 (Interleukin 6)
7.	Interleukin-4 (Interleukin 4)
8.	Thioacetamide (Thioacetamid)
9.	Melatonin
10.	Collagen Receptors

Related Therapies and Procedures

1.	Neoadjuvant Therapy
2.	Therapeutics