Ro 23-9223

a highly lipophilic aromatic retinoid with antiproliferative and sebum supressive effects; structure in first source

Also Known As:

(all-E)-3,7-dimethyl-9-(3,5-dimethyl-2-nonyloxyphenyl)-2,4,6,8-nonatetraenoic acid; Ro-23-9223; Ro23-9223

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

1.	Acne Vulgaris 04/15/2000 - "Despite high embryo levels in hamsters, the data suggest an improved therapeutic index for Ro 23-9223 compared with 13-cis-retinoic acid in a preclinical acne disease model." 04/15/2000 - "Ro 23-9223 is a highly lipophilic aromatic retinoid with antiproliferative and sebum supressive effects in preclinical disease models of acne. "
2.	Drug-Related Side Effects and Adverse Reactions 04/15/2000 - "To investigate the relation between Ro 23-9223 developmental toxicity, drug distribution, and transplacental transfer, groups of pregnant hamsters were given oral doses of 50-500 mg/kg Ro 23-9223 on days 8 and 9 of gestation. "