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1- O- hexadecyl- propanediol- 3- phospho- ganciclovir

an antiviral lipid prodrug of ganciclovir in liposome formulation; structure in first source

Also Known As:

1-O-hexadecylpropanediol-3-phospho-ganciclovir; HDP-P-GCV

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Hypoxanthines: 1
        Guanine: 1793
        Acyclovir: 4814
        Ganciclovir: 3793
        1-O-hexadecyl-propanediol-3-phospho-ganciclovir: 3

Experts

1.	Beadle, J R: 2 articles (01/2001 - 05/2000)
2.	Gardner, M F: 2 articles (01/2001 - 05/2000)
3.	Hostetler, K Y: 2 articles (01/2001 - 05/2000)
4.	Beadle, James R: 1 article (02/2002)
5.	Bergeron-Lynn, Germaine: 1 article (02/2002)
6.	Chaidhawangul, Sunan: 1 article (02/2002)
7.	Cheng, Lingyun: 1 article (02/2002)
8.	Freeman, William R: 1 article (02/2002)
9.	Gardner, Michael F: 1 article (02/2002)
10.	Hostetler, Karl Y: 1 article (02/2002)

Related Diseases

1.	Retinitis 02/01/2002 - "Treatment or prevention of herpes simplex virus retinitis with intravitreally injectable crystalline 1-O-hexadecylpropanediol-3-phospho-ganciclovir." 05/01/2000 - "In the rabbit model of HSV-1 retinitis HDP-P-GCV acts as a long-lasting intravitreal injectable anti-CMV or anti-HSV compound. " 02/01/2002 - "The crystalline ammonium salt of HDP-P-GCV may be a very useful local therapy for herpes family viral retinitis." 05/01/2000 - "Intravitreal injection of HDP-P-GCV with resultant 0.2 mM intravitreal concentration in the HSV-1 retinitis rabbit model demonstrated a complete protection of the retina with the simultaneous treatment strategy and a 4 (P = 0.03) to 6-(P = 0.058) week significant protection of retina with the pretreatment strategies when compared with ganciclovir or blank liposome controls. " 05/01/2000 - "To evaluate the intraocular safety and antiviral treatment efficacy of the sustained lipid prodrug of ganciclovir, 1-O-hexadecylpropanediol-3-phospho-ganciclovir (HDP-P-GCV), as an intravitreal injectable drug system for viral retinitis. "
2.	Infections 01/01/2001 - "HDP-P-GCV is orally active in both MCMV and HSV-1 infection in mice with antiviral activity equivalent to (HSV-1) or greater than oral GCV (MCMV). " 01/01/2001 - "In vitro and in vivo activity of 1-O-hexadecylpropanediol-3-phospho-ganciclovir and 1-O-hexadecylpropanediol-3-phospho-penciclovir in cytomegalovirus and herpes simplex virus infections."

Related Drugs and Biologics

1.	Ammonium Compounds
2.	Salts
3.	Antiviral Agents (Antivirals)
4.	1- O- hexadecyl- propanediol- 3- phospho- ganciclovir
5.	Ganciclovir (Cytovene)
6.	Prodrugs
7.	Liposomes (Liposome)
8.	Lipids
9.	1- O- hexadecylpropanediol- 3- phospho- penciclovir

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Intravitreal Injections