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metallothionein isoform 1

metallothionein isoform gene, downregulated in advanced prostate cancer; has been sequenced

Also Known As:

MT-1X

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Metalloproteins: 164
    - Metallothionein: 1832
      - metallothionein isoform 1: 6

Experts

1.	Garrett, S H: 2 articles (01/2001 - 05/2000)
2.	Sens, D A: 2 articles (01/2001 - 05/2000)
3.	Sens, M A: 2 articles (01/2001 - 05/2000)
4.	Somji, S: 2 articles (01/2001 - 05/2000)
5.	Cherian, M G: 1 article (05/2016)
6.	Ostrakhovitch, E A: 1 article (05/2016)
7.	Song, Y P: 1 article (05/2016)
8.	Chen, Ge: 1 article (10/2005)
9.	Li, Li-jun: 1 article (10/2005)
10.	Xie, Yong: 1 article (10/2005)

Related Diseases

1.	Urinary Bladder Neoplasms (Bladder Cancer) 01/01/2001 - "These studies suggest that the overexpression of MT-1/2 protein in bladder cancer is a result of the overexpression of the MT-1X gene." 01/01/2001 - "The goals of this study were to determine the expression of metallothionein isoform 1 and 2 proteins (MT-1 and MT-2) in bladder cancer and then to determine which MT isoform-specific genes promoted the expression of these proteins. " 01/01/2001 - "Comparison of expression relative to that of beta-actin demonstrated that the level of MT-1X mRNA was overexpressed greatly in bladder cancer as compared to the level in normal bladder tissue. " 01/01/2001 - "Metallothionein isoform 1 and 2 gene expression in the human bladder: evidence for upregulation of MT-1X mRNA in bladder cancer."
2.	Breast Neoplasms (Breast Cancer) 01/01/2002 - "MT-1A, MT-1E, MT-1F, MT-1G, MT-1H, MT-1X and MT-2A but not MT-1B, were detected in breast cancer tissue samples. " 05/01/2016 - "The silencing of wild-type p53 (wt-p53) in epithelial breast cancer MCF7 cells affected the basal level of MT-2A RNA, whereas the levels of MT-1A and MT-1X RNA remained largely unchanged. " 08/01/2000 - "Increased expression of MT-1E, as well as MT-1X and MT-2A, protects against metal toxicity in PMC42 breast cancer cells."
3.	Prostatic Neoplasms (Prostate Cancer) 05/01/2000 - "No expression of the MT-1X gene was demonstrated in cases of advanced prostate cancer. " 05/01/2000 - "Expression of MT-1X mRNA is downregulated in advanced prostate cancer. " 05/01/2000 - "Using normal prostate tissue dissected from glands removed for prostate cancer, it was demonstrated that MT protein expression in the normal prostate is supported by mRNA from the MT-1A, MT-1E, MT-1X, and MT-2A genes. " 05/01/2000 - "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer."
4.	Pancreatic Neoplasms (Pancreatic Cancer) 10/01/2005 - "The expression of MT proteins was upregulated and MT-1B, MT-1E, MT-1X, MT-2A genes overexpressed in human pancreatic cancer drug-resistant cell lines (P < 0.05). " 10/01/2005 - "MT protein expression in the pancreatic cancer cell strains was encoded by MT-1A, MT-1B, MT-1E, MT-1F, MT-1G, MT-1X, and MT-2A genes. "
5.	Neoplasms (Cancer) 01/01/2001 - "The level of MT-1X expression did not vary with tumor grade. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Protein Isoforms (Isoforms)
3.	metallothionein isoform 1
4.	Messenger RNA (mRNA)
5.	RNA (Ribonucleic Acid)
6.	Metals
7.	Actins (F Actin)