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syringolin A

a cyclic dipeptide composed of the two non-proteinogenic amino acids

Also Known As:

syringolin-A

Networked: 6 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - syringolin A: 6
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - syringolin A: 6

Experts

1.	Dudler, Robert: 3 articles (12/2014 - 11/2006)
2.	Bachmann, André S: 2 articles (04/2016 - 07/2010)
3.	Kaiser, Markus: 2 articles (03/2013 - 07/2010)
4.	Ambadi, Sudhakar: 1 article (04/2016)
5.	Chang, Chia-En A: 1 article (04/2016)
6.	Ibarra-Rivera, Tannya R: 1 article (04/2016)
7.	Opoku-Ansah, John: 1 article (04/2016)
8.	Pirrung, Michael C: 1 article (04/2016)
9.	Roberts, Christopher C: 1 article (04/2016)
10.	Yco, Lisette P: 1 article (04/2016)

Related Diseases

1.	Neoplasms (Cancer) 04/15/2016 - "It is particularly effective against kidney tumor cell lines, with >250-fold higher anti-tumor activities than observed with the natural product syringolin A. " 12/01/2006 - "The goal of this study was to investigate whether syringolin A exhibits anti-proliferative properties in cancer cells. "
2.	Ovarian Neoplasms (Ovarian Cancer) 12/01/2006 - "The treatment of human neuroblastoma (NB) cells (SK-N-SH and LAN-1) and human ovarian cancer cells (SKOV3) with syringolin A (0-100 microm) inhibited cell proliferation in a dose-dependent manner. " 12/01/2006 - "Syringolin A, a new plant elicitor from the phytopathogenic bacterium Pseudomonas syringae pv. syringae, inhibits the proliferation of neuroblastoma and ovarian cancer cells and induces apoptosis." 07/15/2010 - "In this study, we examined the effects of syringolin A (SylA) and glidobactin A (GlbA) as well as two synthetic SylA-analogs (SylA-PEG and SylA-LIP) in human neuroblastoma (SK-N-SH), human multiple myeloma (MM1.S, MM1.RL, and U266), and human ovarian cancer (SKOV-3) cells. "
3.	Neuroblastoma 12/01/2006 - "The treatment of human neuroblastoma (NB) cells (SK-N-SH and LAN-1) and human ovarian cancer cells (SKOV3) with syringolin A (0-100 microm) inhibited cell proliferation in a dose-dependent manner. " 12/01/2006 - "Syringolin A, a new plant elicitor from the phytopathogenic bacterium Pseudomonas syringae pv. syringae, inhibits the proliferation of neuroblastoma and ovarian cancer cells and induces apoptosis." 07/15/2010 - "In this study, we examined the effects of syringolin A (SylA) and glidobactin A (GlbA) as well as two synthetic SylA-analogs (SylA-PEG and SylA-LIP) in human neuroblastoma (SK-N-SH), human multiple myeloma (MM1.S, MM1.RL, and U266), and human ovarian cancer (SKOV-3) cells. "
4.	Multiple Myeloma 07/15/2010 - "In this study, we examined the effects of syringolin A (SylA) and glidobactin A (GlbA) as well as two synthetic SylA-analogs (SylA-PEG and SylA-LIP) in human neuroblastoma (SK-N-SH), human multiple myeloma (MM1.S, MM1.RL, and U266), and human ovarian cancer (SKOV-3) cells. "
5.	Disease Progression 12/04/2014 - "For host colonization and disease progression, strains of this bacterium utilize an array of type III-secreted effectors and other virulence factors, including small secreted molecules such as syringolin A, a peptide derivative that inhibits the eukaryotic proteasome. "

Related Drugs and Biologics

1.	glidobactin A
2.	Proteasome Inhibitors
3.	Proteasome Endopeptidase Complex (Proteasome)
4.	Virulence Factors (Pathogenicity Factors)
5.	Solutions
6.	Proteins (Proteins, Gene)
7.	Cyclic Peptides
8.	Peptides (Polypeptides)