|1.||Roelofs, Anke J: 2 articles (02/2012 - 04/2007)|
|2.||Stratton, Steven P: 2 articles (12/2009 - 04/2007)|
|3.||Powell, Marianne B: 2 articles (12/2009 - 04/2007)|
|4.||Floret, Simon: 2 articles (01/2006 - 08/2004)|
|5.||Heymann, Dominique: 1 article (02/2012)|
|6.||Redini, Françoise: 1 article (02/2012)|
|7.||Rogers, Michael J: 1 article (02/2012)|
|8.||Brion, Régis: 1 article (02/2012)|
|9.||Moriceau, Gatien: 1 article (02/2012)|
|10.||Ebetion, Frank H: 1 article (02/2012)|
12/01/2009 - "Regardless of delivery vehicle apomine treatment caused a significant reduction in tumor incidence. "
05/01/2001 - "Seven solid cancer patients who participated in an ongoing Phase I study of Apomine and received the starting dose level of 125 mg/m(2)/day x 14 days every 3 weeks underwent a pharmacokinetic study on day 14 of the first course. "
05/01/2001 - "Phase I pharmacokinetic trial and correlative in vitro phase II tumor kinetic study of Apomine (SR-45023A), a novel oral biphosphonate anticancer drug."
04/15/2007 - "Apomine inhibited the development of osteolytic lesions and prevented the tumor-induced decreases in BMD. "
04/15/2007 - "Apomine caused a decrease in serum paraprotein and a decrease in tumor burden. "
|2.||Melanoma (Melanoma, Malignant)
01/01/2006 - "The objective of the current study was to evaluate the efficacy and safety of continuously administered Apomine (SR-45023A), a novel bisphosphonate, in patients with previously treated metastatic malignant melanoma. "
01/01/2006 - "A phase II open-label trial of apomine (SR-45023A) in patients with refractory melanoma."
04/01/2007 - "Cytotoxic activity of Apomine is due to a novel membrane-mediated cytolytic mechanism independent of apoptosis in the A375 human melanoma cell line."
01/01/2006 - "Adult patients with previously treated metastatic melanoma received Apomine 100 mg orally, twice daily (total dose 200 mg per day) continuously for 28 days (defined as a cycle). "
12/01/2009 - "This research was focused on the development of a new delivery approach for chemoprevention of melanoma using topically delivered apomine. "
|3.||Osteosarcoma (Osteogenic Sarcoma)
02/01/2012 - "The results from this study revealed that combination therapy with apomine and lovastatin may be a novel treatment strategy for osteosarcoma."
02/01/2012 - "Apomine and lovastatin synergistically decreased viability and induced apoptosis in both murine and human osteosarcoma cell lines. "
02/01/2012 - "The authors of this report investigated the effect of combined treatment with apomine and lovastatin in vitro on human and murine osteosarcoma cell lines and in vivo using a murine syngeneic model of osteosarcoma. "
02/01/2012 - "Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth."
02/01/2012 - "Finally, treatment of POS-1 osteosarcoma-bearing mice with a combination of apomine and lovastatin significantly reduced tumor progression in these mice compared with single treatments, which had no effect at the doses used. "
09/01/2006 - "The data in the following tables have been retrieved from the Clinical Trials Knowledge Area of Prous Science Integrity, the drug discovery and development portal, http://integrity.prous.com This issue focuses on the following selection of drugs: A-007, A6, adalimumab, adenosine triphosphate, alefacept, alemtuzumab, AllerVax Ragweed, amphora, anakinra, angiotensin-(1-7), anidulafungin, apomine, aripiprazole, atomoxetine hydrochloride, avanafil; BAL-8557, becatecarin, bevacizumab, biphasic insulin aspart, BMS-188797, bortezomib, bosentan, botulinum toxin type B, brivudine; Calcipotriol/betamethasone dipropionate, caspofungin acetate, catumaxomab, certolizumab pegol, cetuximab, CG-0070, ciclesonide, cinacalcet hydrochloride, clindamycin phosphate/benzoyl peroxide, cryptophycin 52, Cypher; Dabigatran etexilate, darapladib, darbepoetin alfa, decitabine, deferasirox, desloratadine, dexanabinol, dextromethorphan/quinidine sulfate, DMF, drotrecogin alfa (activated), duloxetine hydrochloride; E-7010, edaravone, efalizumab, emtricitabine, entecavir, eplerenone, erlotinib hydrochloride, escitalopram oxalate, estradiol valerate/dienogest, eszopiclone, exenatide, ezetimibe; Fondaparinux sodium, fulvestrant; Gefitinib, gestodene, GYKI-16084; Hyaluronic acid, hydralazine hydrochloride/isosorbide dinitrate; Imatinib mesylate, indiplon, insulin glargine; Juzen-taiho-to; Lamivudine/zidovudine/abacavir sulfate, L-arginine hydrochloride, lasofoxifene tartrate, L-BLP-25, lenalidomide, levocetirizine, levodopa/carbidopa/entacapone, lexatumumab, lidocaine/prilocaine, lubiprostone, lumiracoxib; MAb-14.18, mitoquidone; Natalizumab, neridronic acid, neuradiab; Olpadronic acid sodium salt, omalizumab; p53-DC vaccine, parathyroid hormone (human recombinant), peginterferon alfa-2a, peginterferon alfa-2b, pemetrexed disodium, perifosine, pimecrolimus, prasterone, prasugrel, PRO-2000, Pseudostat; R24, rasburicase, RHAMM R3 peptide, rilonacept, rosuvastatin calcium, rotavirus vaccine, rufinamide; Sabarubicin hydrochloride, SHL-749, sirolimus-eluting stent, SLx-2101, sodium butyrate, sorafenib, SU-6668; TachoSil, tadalafil, taxus, tegaserod maleate, telbivudine, tenofovir disoproxil fumarate, teriparatide, tetramethylpyrazine, teverelix, tiotropium bromide, tipifarnib, tirapazamine, tolvaptan, TransvaxTM hepatitis C vaccine, treprostinil sodium; Valganciclovir hydrochloride, valsartan/amlodipine, vandetanib, vardenafil hydrochloride hydrate, vatalanib succinate, veglin, voriconazole; Yttrium 90 (90Y) ibritumomab tiuxetan; Zileuton, zotarolimus, zotarolimus-eluting stent."
|5.||Breast Neoplasms (Breast Cancer)
04/08/2005 - "Our study suggests apomine is a potential anti-neoplastic drug in breast cancer treatment."
04/08/2005 - "The aims of this study were to determine the effect of apomine on the growth of two breast cancer cell lines, MCF-7 and MDA-MB-231, to ascertain whether any growth inhibitory effects found were due to induction of apoptosis, and to investigate the mechanism of action of apomine. "
04/08/2005 - "We conclude that apomine induces apoptosis in breast cancer cells, an effect that is independent of oestrogen receptor status and is not via inhibition of the mevalonate pathway. "
04/08/2005 - "Induction of apoptosis in breast cancer cells by apomine is mediated by caspase and p38 mitogen activated protein kinase activation."
|2.||Ethanol (Ethyl Alcohol)
|3.||Interleukin 1 Receptor Antagonist Protein (Anakinra)
|5.||Succinic Acid (Succinate)