oxysophoridine

01/01/2012 - "To investigate the protective effects of oxysophoridine (OSR) on primary cultured hippocampus neurons subjected to anoxia injury in neonatal rats and its mechanism. "

07/01/2013 - "In this study, we investigated the neuroprotective effect of oxysophoridine on ischemia and ischemia-like insults. "
07/01/2013 - "Protection by oxysophoridine was studied at the in vivo level using a model of middle cerebral artery occlusion in mice and at the in vitro level using primary rat hippocampal neuronal cultures exposed to oxygen-glucose deprivation, a model of ischemia-like injury. "

03/01/2012 - "To observe the in vivo effects of oxysophoridine on hepatocellular carcinoma in mice and to study the related mechanisms. "
03/01/2012 - "Compared with the tumor weight of the control group (2.75±0.66 g), oxysophoridine significantly suppressed hepatocellular carcinoma growth in mice (P <0.01), with 0.82±0.36 g, 0.57±0.22 g, and 1.22±0.67 g for the tumor weight in the low, moderate, and high dose treatment group, respectively. "
03/01/2012 - "Oxysophoridine suppresses the growth of hepatocellular carcinoma in mice: in vivo and cDNA microarray studies."
03/01/2012 - "Oxysophoridine was a promising compound for developing drugs against hepatocellular carcinoma, and its anti-hepatoma effect was probably related to osteoprotegerin activation."
03/01/2012 - "C57BL mice were inoculated with mouse hepatoma H22 cells subcutaneously, then divided into 5 groups (14 per group), and treated with oxysophoridine (50, 100, or 150 mg/kg) or cisplatin (4 mg/kg) for 10 days. "

02/01/2023 - "Oxysophoridine protects against cerebral ischemia/reperfusion injury via inhibition of TLR4/p38MAPK‑mediated ferroptosis."
05/25/2013 - "These results provided evidence that oxysophoridine plays a protective role in cerebral ischemia/reperfusion injury. "
05/25/2013 - "Protective effect of oxysophoridine on cerebral ischemia/reperfusion injury in mice."
07/01/2013 - "These findings suggested that oxysophoridine may be a potential neuroprotective agent for cerebral ischemia injury. "
07/01/2013 - "Anti-apoptotic and neuroprotective effects of oxysophoridine on cerebral ischemia both in vivo and in vitro."

02/01/2023 - "Oxysophoridine protects against cerebral ischemia/reperfusion injury via inhibition of TLR4/p38MAPK‑mediated ferroptosis."
05/25/2013 - "These results provided evidence that oxysophoridine plays a protective role in cerebral ischemia/reperfusion injury. "
05/25/2013 - "Protective effect of oxysophoridine on cerebral ischemia/reperfusion injury in mice."
12/01/2015 - "Anti-inflammation Effects of Oxysophoridine on Cerebral Ischemia-Reperfusion Injury in Mice."
05/25/2013 - "Our experimental findings indicated that oxysophoridine has a neuroprotective effect against cerebral ischemia/reperfusion injury in mice, and that the effect may be due to its ability to inhibit oxidative stress and expression of the N-methyl-D-aspartate receptor subunit NR1. "