titanocene

01/01/2023 - "The titanocene functionalized materials were studied as antitumoral agents in the breast cancer lines MCF-7 and MDA-MB-231. "
04/10/2015 - "Controlled release of titanocene into the hybrid nanofibrous scaffolds to prevent the proliferation of breast cancer cells."
01/01/2014 - "New titanocene derivatives with high antiproliferative activity against breast cancer cells."
06/01/2013 - "A series of novel titanocene-complexes has been prepared and evaluated for their growth regulatory effects in MCF7 and SkBr3 breast cancer cells. "
06/01/2013 - "Synthesis, characterization and cytotoxic activity on breast cancer cells of new half-titanocene derivatives."

01/01/2012 - "Study of the cytotoxicity and particle action in human cancer cells of titanocene-functionalized materials with potential application against tumors."
01/01/2008 - "Synthesis and cytotoxicity studies of new dimethylamino-functionalised and aryl-substituted titanocene anti-cancer agents."
03/01/2016 - "Enantiopure titanocene complexes--direct evidence for paraptosis in cancer cells."
02/01/2016 - "Correction for 'Enantiopure titanocene complexes--direct evidence for paraptosis in cancer cells' by Melchior Cini et al., Metallomics, 2016, DOI: 10.1039/c5mt00297d."
02/01/2016 - "Correction: Enantiopure titanocene complexes--direct evidence for paraptosis in cancer cells."

01/01/2019 - "Following promising recent in vitro and in vivo studies of the anticancer efficacies of heterometallic titanocene-gold chemotherapeutic candidates against renal cancer, we report here on the synthesis, characterization, stability studies and biological evaluation of a new titanocene complex containing a gold-triethylphosphane fragment [(η-C5H5)2TiMe(μ-mba)Au(PEt3)] (4) Titanofin. "
11/24/2014 - "Organometallic Titanocene-Gold Compounds as Potential Chemotherapeutics in Renal Cancer. "
01/01/2019 - "Heterometallic titanocene-based compounds containing gold(I)-phosphane fragments have been extremely successful against renal cancer in vitro and in vivo. "
01/01/2019 - "In summary, bimetallic titanocene-gold phosphane complexes (Titanocref 2 and Titanofin 4) are very promising candidates for further preclinical evaluations for the treatment of renal cancer."
03/01/2006 - "The benzyl-substituted unbridged titanocene bis-[(p-methoxybenzyl)cyclopentadienyl] titanium(IV) dichloride (Titanocene Y) was tested in vitro against human renal cancer cells (Caki-1), in which it showed an IC50 value of 36 x 10 mol/l. "

07/01/1985 - "Activity of titanocene dihalides against a human colon carcinoma heterotransplanted to athymic mice."
05/01/1987 - "In the present study, the antitumor activity of some titanocene derivatives (C5H5)2TiX2 (I, X = Cl; II, X = Br; III, X = cis-OOCCH = CHCOOH; IV, X = p-SC6H4NH3+Cl-) was investigated against B16 melanoma and colon 38 carcinoma. "
01/01/1987 - "Tumor inhibition by titanocene complexes: influence upon two xenografted human lung carcinomas."
01/01/1989 - "The present study deals with the influence of some bis(eta 5-cyclopentadienyl)titanium(IV) (titanocene) complexes, mainly represented by titanocene dichloride, on the development of several human gastrointestinal (GI) carcinomas (one stomach, seven colon, four sigmoid, and two rectal adenocarcinomas), all xenografted to athymic mice. "
04/01/1989 - "Colon 38 carcinoma and Lewis lung carcinoma revealed to be more sensitive to the titanocene tetrachloroferrate derivative than solid B16 melanoma, whereby the growth development of the aforementioned tumors was suppressed by 70-76% of control tumor size to T/C ratios amounting to 24-30%. "

07/01/2006 - "The objectives of this study are to examine the effects of these titanocene compounds on prostate cancer cells. "
07/01/2006 - "Novel titanocene anti-cancer drugs and their effect on apoptosis and the apoptotic pathway in prostate cancer cells."
01/01/2019 - "Preparation of Titanocene-Gold Compounds Based on Highly Active Gold(I)-N-Heterocyclic Carbene Anticancer Agents: Preliminary in vitro Studies in Renal and Prostate Cancer Cell Lines."