spermatogenesis associated factor (SPAF)

a member of the AAA-protein family specific to early spermatogensis and malignant conversion; amino acid sequence in first source; GenBank AF049099
Also Known As:
SPAF; spermatogenesis related factor-2
Networked: 54 relevant articles (5 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Hart, Robert G: 5 articles (04/2007 - 10/2002)
2. Lip, Gregory Y H: 4 articles (02/2014 - 10/2002)
3. Weiss, Norbert: 2 articles (06/2015 - 04/2015)
4. Gelbricht, Vera: 2 articles (06/2015 - 04/2015)
5. Beyer-Westendorf, Jan: 2 articles (06/2015 - 04/2015)
6. Michalski, Franziska: 2 articles (06/2015 - 04/2015)
7. Sahin, Kurtulus: 2 articles (06/2015 - 04/2015)
8. Tittl, Luise: 2 articles (06/2015 - 04/2015)
9. Endig, Heike: 2 articles (06/2015 - 04/2015)
10. Ebertz, Franziska: 2 articles (06/2015 - 04/2015)

Related Diseases

1. Stroke (Strokes)
2. Atrial Fibrillation
3. Thromboembolism
4. Heart Failure
10/01/1994 - "In patients with congestive heart failure on antiarrhythmic therapy, the SPAF trial has shown an increase in cardiac mortality and arrhythmic deaths. "
07/01/2007 - "Stroke risk was compared in 193 patients with atrial fibrillation using the Framingham equation; an atrial fibrillation-specific Framingham equation; the Congestive heart failure, Hypertension, Age, Diabetes and Stroke (CHADS(2)) score; the Stroke Prevention and Atrial Fibrillation (SPAF) scheme; and the Scottish Intercollegiate Guidelines Network (SIGN) guidelines. "
09/01/2005 - "The proportions of patients classified as having high, moderate, and low risk of stroke among the following CCSs were compared: the Atrial Fibrillation Investigators (AFI), the Stroke Prevention in Atrial Fibrillation (SPAF), the CHADS(2) (an acronym for congestive heart failure, hypertension, age >75 years, diabetes mellitus, and prior stroke or transient ischemic attack), and the American College of Chest Physicians (ACCP). "
06/01/2005 - "To examine further the relations of plasma von Willebrand factor (vWf, an index of endothelial damage and dysfunction) and soluble P-selectin (sP-sel, an index of platelet activation) concentrations to the presence and onset of clinical congestive heart failure (CHF) and the degree of left ventricular (LV) dysfunction in patients taking part in the SPAF (stroke prevention in atrial fibrillation) study. "
01/01/2001 - "Anticoagulation with warfarin using international normalised ratios (INRs) ranging from 2.0 to 3.0 is recommended for patients with NVAF, who have any of the risk factors identified by the Atrial Fibrillation Investigators (AFI) [previous stroke or TIA, history of hypertension, diabetes mellitus, advanced age (> or = 65 years old), congestive heart failure and coronary artery disease], the American College of Chest Physicians (ACCP) [increased age (> 75 years old), prior stroke, hypertension and heart failure], or the Stroke Prevention in Atrial Fibrillation (SPAF) investigators [women > 75 years old, prior stroke, systolic blood pressure > 160mm Hg, recent heart failure, and fractional shortening < 25% on echocardiography]. "
5. Embolism (Embolus)

Related Drugs and Biologics

1. Aspirin (Acetylsalicylic Acid)
2. Warfarin (Coumadin)
3. P-Selectin
4. von Willebrand Factor
5. Apoprotein(a) (Apolipoprotein (a))
6. Semaphorins (Semaphorin)
7. Tenascin
8. Vimentin
9. Retinaldehyde (Retinal)
10. Protein Kinase C

Related Therapies and Procedures

1. Carotid Endarterectomy
2. Hormone Replacement Therapy (Therapy, Hormone Replacement)