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RPR 208566

structure in first source

Also Known As:

2-(3-carbamimidoylbenzyl)-3-((3',4'-dimethoxybiphenyl-4-carbonyl)amino)butyric acid methyl ester trifluoroacetate; RPR-208566; RPR208566

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Bentley, R: 1 article (02/2000)
2.	Bostwick, J: 1 article (02/2000)
3.	Brown, K: 1 article (02/2000)
4.	Chu, V: 1 article (02/2000)
5.	Colussi, D: 1 article (02/2000)
6.	Czekaj, M: 1 article (02/2000)
7.	Heran, C: 1 article (02/2000)
8.	Kasiewski, C: 1 article (02/2000)
9.	Klein, S: 1 article (02/2000)
10.	Leadley, R: 1 article (02/2000)

Related Diseases

1.	Thrombosis (Thrombus) 02/18/2000 - "When administered at 500 microgram/kg+50 microgram/kg/min, RPR208566 prolonged time-to-occlusion to 56+/-4 min (vs. 18+/-2 min for vehicle) and reduced thrombus mass to 3.0+/-0.7 mg (vs. 7.3+/-0.6 mg for vehicle). " 02/18/2000 - "RPR208566, heparin, and argatroban dose-dependently increased time-to-occlusion and reduced thrombus mass. " 02/18/2000 - "Our objective was to evaluate the antithrombotic efficacy of the novel factor Xa inhibitor, 2-(3-carbamimidoyl-benzyl)-3-[(3', 4'dimethoxy-biphenyl-4-carbonyl)-amino]-butyric acid methyl ester-trifluoroacetate (RPR208566), in a well-established rat model of arterial thrombosis, and to compare the results with those obtained with argatroban and heparin, direct and indirect inhibitors of thrombin, respectively. "
2.	Carotid Artery Thrombosis 02/18/2000 - "Antithrombotic efficacy of RPR208566, a novel factor Xa inhibitor, in a rat model of carotid artery thrombosis."

Related Drugs and Biologics

1.	Factor Xa Inhibitors
2.	Butyric Acid (Butanoic Acid)
3.	Trifluoroacetic Acid (Trifluoroacetate)
4.	Thrombin
5.	Heparin (Liquaemin)
6.	Esters
7.	argatroban (MPQA)
8.	diphenyl (biphenyl)