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SB 243213

a 5-HT2c inverse agonist; structure in first source

Also Known As:

5-methyl-1-((2-((2-methyl-3-pyridyl)oxy)pyridyl)carbamoyl)-6-trifluoromethylindoline; SB-243213

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - SB 243213: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - SB 243213: 2

Experts

1.	Glazebrook, John: 1 article (11/2009)
2.	Grayson, Ben: 1 article (11/2009)
3.	Kirk, Shona L: 1 article (11/2009)
4.	Neill, Joanna C: 1 article (11/2009)
5.	Reynolds, Gavin P: 1 article (11/2009)
6.	Blackburn, T P: 1 article (08/2001)
7.	Bromidge, S M: 1 article (08/2001)
8.	Forbes, I T: 1 article (08/2001)
9.	Gager, T L: 1 article (08/2001)
10.	Holland, V: 1 article (08/2001)

Related Diseases

1.	Body Weight (Weight, Body) 08/01/2001 - "Furthermore, in rodents, SB-243213 did not affect seizure threshold, did not increase body weight or induce catalepsy, but attenuated the haloperidol-induced catalepsy. " 11/01/2009 - "Olanzapine (2 mg/kg) and the 5-HT2C antagonist SB 243213 (1 mg/kg), but not the histamine H1 antagonist mepyramine (1 mg/kg), produced significant increases in percentage body weight above vehicle; olanzapine showed a significantly greater effect than SB 243213. "
2.	Weight Gain 11/01/2009 - "Haloperidol (0.1 mg/kg) alone or with mepyramine had no significant effects on weight gain, while with SB 243213 and with both SB 243213 and mepyramine, it showed olanzapine-like increases in weight. "
3.	Schizophrenia (Dementia Praecox) 08/01/2001 - "SB-243213 also modulates dopaminergic transmission, lacks pro-psychotic properties and may have utility in the treatment of schizophrenia and motor disorders."
4.	Catalepsy 08/01/2001 - "Furthermore, in rodents, SB-243213 did not affect seizure threshold, did not increase body weight or induce catalepsy, but attenuated the haloperidol-induced catalepsy. "
5.	Motor Disorders 08/01/2001 - "SB-243213 also modulates dopaminergic transmission, lacks pro-psychotic properties and may have utility in the treatment of schizophrenia and motor disorders."

Related Drugs and Biologics

1.	Serotonin 5-HT2 Receptor Antagonists
2.	Pyrilamine (Mepyramine)
3.	Histamine H1 Antagonists
4.	Olanzapine (Zyprexa)
5.	Haloperidol (Haldol)