vitamin D 1-alpha hydroxylase
regulated by dexamethasone in mouse kidney
Also Known As:
1,25(OH)2D3 hydroxylase; 1,25-dihydroxyvitamin D3 1-alpha hydroxylase; P450C1 alpha; P450VD1-alpha; vitamin D1-alpha hydroxylase
Networked: 3
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Bio-Agent Context: Research Results
Experts
Related Diseases
| 1. | Rickets (Rachitis)
12/01/1997
- " The gene encoding P450c1 alpha was localized to chromosome 12, where the 1 alpha-hydroxylase deficiency syndrome, vitamin D-dependent rickets type 1 (VDDR-1), has been localized. " 10/01/2000
- " In late 1997, we reported the cloning of the human cDNA and gene from keratinocytes, and established that P450c1 alpha mutations cause vitamin D-dependent rickets, type I, while three other groups reported the cloning of the rodent enzyme. " 08/01/1999
- " Mutations in the P450c1 alpha gene, located on chromosome 12, cause 1 alpha-hydroxylase deficiency, also known as vitamin D-dependent rickets type I, an autosomal recessive disease characterized by rickets and impaired growth due to failure of renal synthesis of 1,25(OH)2D. "
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