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CPI 1189

structure in first source

Also Known As:

CPI-1189

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Butanes: 12
        CPI 1189: 4

Experts

1.	Flitter, W D: 2 articles (03/2001 - 12/2000)
2.	Garland, W A: 2 articles (03/2001 - 12/2000)
3.	Li, Chengrui: 1 article (01/2021)
4.	Li, Yong-Jun: 1 article (01/2021)
5.	Sun, Jianhong: 1 article (01/2021)
6.	Yang, Chengliang: 1 article (01/2021)
7.	Zhan, Yueli: 1 article (01/2021)
8.	Müller, Thomas: 1 article (12/2002)
9.	Irwin, I: 1 article (03/2001)
10.	Kusdra, L: 1 article (03/2001)

Related Diseases

1.	Necrosis 01/01/2021 - "Furthermore, in SH-SY5Y cells and cortical neurons, CPI-1189 alleviated OGDR-induced programmed necrosis by inhibiting mitochondrial p53-cyclophilin D-adenine nucleotide translocase 1 association, mitochondrial depolarization, and lactate dehydrogenase release to the medium. " 03/02/2001 - "CPI-1189, a drug currently undergoing clinical evaluation as a treatment for the dementia associated with AIDS, is shown in this paper to mitigate apoptosis induced by TNFalpha, gp120, and necrosis induced by quinolinic acid. "
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 12/01/2002 - "Since the importance of neuroprotection is emerging, in particular in neurodegenerative diseases with concomitant observed immunological pro-apoptotic alterations in the central nervous system, long-term application of CPI-1189 could represent a promising future therapeutic alternative, in addition to neuroprotective compounds such as selegiline."
3.	AIDS Dementia Complex 12/01/2000 - "Additionally, CPI-1189 treatment may protect against TNF-alpha induced apoptosis and astrogliosis in AIDS dementia complex. " 12/01/2000 - "CPI-1189 prevents apoptosis and reduces glial fibrillary acidic protein immunostaining in a TNF-alpha infusion model for AIDS dementia complex."
4.	Gliosis 12/01/2000 - "Additionally, CPI-1189 treatment may protect against TNF-alpha induced apoptosis and astrogliosis in AIDS dementia complex. "
5.	Dementia (Dementias) 03/02/2001 - "In addition, CPI-1189 mitigates the cell death produced by supernatants from cultured macrophages obtained from patients with AIDS dementia. " 03/02/2001 - "CPI-1189 attenuates effects of suspected neurotoxins associated with AIDS dementia: a possible role for ERK activation." 03/02/2001 - "CPI-1189, a drug currently undergoing clinical evaluation as a treatment for the dementia associated with AIDS, is shown in this paper to mitigate apoptosis induced by TNFalpha, gp120, and necrosis induced by quinolinic acid. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Quinolinic Acid
3.	Selegiline (E250)
4.	Neurotoxins
5.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
6.	Glial Fibrillary Acidic Protein
7.	ATP Translocases Mitochondrial ADP