NPS 1506

12/01/2000 - "In the present study, we evaluated the efficacy of NPS 1506 in a model of parasagittal fluid percussion brain trauma in the anesthetized rat. "
09/15/2004 - "These data also show that the previously reported broad efficacy of MgSO(4) or NPS 1506 observed shortly after brain trauma could not be detected 8 months post-injury."
12/01/2000 - "Since memory dysfunction and hippocampal damage are common and potentially related consequences of brain trauma in humans, our results suggest that NPS 1506 treatment may have clinical utility."
12/01/2000 - "NPS 1506 attenuates cognitive dysfunction and hippocampal neuron death following brain trauma in the rat."
09/15/2004 - "Previous studies have shown that magnesium salts and the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, NPS 1506, attenuated short-term cognitive deficits and histopathological changes associated with traumatic brain injury (TBI). "

10/01/2000 - "These findings indicate that NPS 1506 improved measures of brain tissue edema (at 24 hours but not at 48 hours) and ion homeostasis, and this improvement was not related to other measures of outcome."

12/01/2000 - "NPS 1506 attenuates cognitive dysfunction and hippocampal neuron death following brain trauma in the rat."

10/01/2000 - "We examined whether NPS 1506, a novel uncompetitive N-methyl-D-aspartate receptor antagonist, influences neurological outcome following closed head trauma (CHT) in rats. "
10/01/2000 - "NPS 1506: a novel NMDA receptor antagonist: neuroprotective effects in a model of closed head trauma in rats."

10/01/2000 - "NPS 1506 caused no significant change in ischemic tissue volume or hemorrhagic necrosis volume in the injured hemisphere at 24 hours or 48 hours. "