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Bacteroides fragilis toxin

GenBank AB026624, AB026625 (bft-1), and AB026626 (bft-2); do not confuse with Bft gene product

Also Known As:

Bft protein, Bacteroides fragilis

Networked: 15 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Biological Factors: 2472
- Biological Toxins: 20
  - Bacterial Toxins: 814
    - Bacteroides fragilis toxin: 15
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Metalloproteases: 8276
        Metalloendopeptidases: 70
        Bacteroides fragilis toxin: 15
      - Endopeptidases: 633
        Metalloendopeptidases: 70
        Bacteroides fragilis toxin: 15

Experts

1.	Sears, Cynthia L: 5 articles (01/2022 - 01/2015)
2.	Wu, Shaoguang: 3 articles (01/2022 - 02/2018)
3.	Hwang, Soonjae: 3 articles (10/2020 - 09/2019)
4.	Jo, Minjeong: 3 articles (10/2020 - 09/2019)
5.	Rhee, Ki-Jong: 3 articles (10/2020 - 09/2019)
6.	Hwang, Samnoh: 2 articles (10/2020 - 01/2020)
7.	Yi, Hye Chin: 2 articles (10/2020 - 01/2020)
8.	Lee, Chang Gun: 2 articles (01/2020 - 09/2019)
9.	Park, Chan Oh: 2 articles (01/2020 - 09/2019)
10.	Boleij, Annemarie: 2 articles (01/2019 - 01/2015)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 01/15/2015 - "The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients." 01/01/2019 - "Enterotoxigenic Bacteroides fragilis (ETBF) produces Bacteroides fragilis toxin (BFT), which is associated with acute diarrheal, inflammatory bowel disease, and colorectal cancer (CRC). " 01/01/2019 - "This bacterium is found more frequently in people with colorectal cancer (CRC) and causes tumor formation in the distal colon of multiple intestinal neoplasia (Apcmin/+ ) mice; tumor formation is dependent on ETBF-secreted Bacteroides fragilis toxin (BFT). " 01/15/2015 - "Enterotoxigenic Bacteroides fragilis (ETBF) produces the Bacteroides fragilis toxin, which has been associated with acute diarrheal disease, inflammatory bowel disease, and colorectal cancer (CRC). " 01/01/2021 - "Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort."
2.	Colitis 10/28/2020 - "Enterotoxigenic Bacteroides fragilis (ETBF) is a gut commensal bacterium and reported to be a potent initiator of colitis via secretion of the Bacteroides fragilis toxin (BFT). " 01/01/2020 - "The human commensal bacterium, enterotoxigenic Bacteroides fragilis (ETBF) secretes the Bacteroides fragilis toxin (BFT) which is necessary and sufficient to cause colitis. " 09/14/2019 - "Enterotoxigenic Bacteroides fragilis (ETBF) is human intestinal commensal bacterium and a potent initiator of colitis through secretion of the metalloprotease Bacteroides fragilis toxin (BFT). "
3.	Carcinogenesis 02/14/2018 - "Using ApcMin mice colonized with the human pathobiont enterotoxigenic Bacteroides fragilis (ETBF) as a model of microbe-induced colon tumorigenesis, we show that the Bacteroides fragilis toxin (BFT) triggers a pro-carcinogenic, multi-step inflammatory cascade requiring IL-17R, NF-κB, and Stat3 signaling in colonic epithelial cells (CECs). " 01/01/2019 - "One of the first discovered bacterial mediators involves Bacteroides fragilis toxin (BFT, also named as fragilysin), a metalloprotease encoded by enterotoxigenic Bacteroides fragilis (ETBF) that causes barrier disruption and inflammation of the colon, leads to tumorigenesis in susceptible mice, and is enriched in the mucosa of IBD and CRC patients. "
4.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/01/2019 - "Enterotoxigenic Bacteroides fragilis (ETBF) produces Bacteroides fragilis toxin (BFT), which is associated with acute diarrheal, inflammatory bowel disease, and colorectal cancer (CRC). " 01/15/2015 - "Enterotoxigenic Bacteroides fragilis (ETBF) produces the Bacteroides fragilis toxin, which has been associated with acute diarrheal disease, inflammatory bowel disease, and colorectal cancer (CRC). "
5.	Inflammation (Inflammations) 03/01/2000 - "Bacteroides fragilis toxin (BFT) has been shown to be capable of inducing intestinal mucosal inflammation in animals. " 01/01/2019 - "One of the first discovered bacterial mediators involves Bacteroides fragilis toxin (BFT, also named as fragilysin), a metalloprotease encoded by enterotoxigenic Bacteroides fragilis (ETBF) that causes barrier disruption and inflammation of the colon, leads to tumorigenesis in susceptible mice, and is enriched in the mucosa of IBD and CRC patients. "

Related Drugs and Biologics

1.	Metalloproteases (Metalloproteinases)
2.	Proteins (Proteins, Gene)
3.	Peptide Hydrolases (Proteases)
4.	fragilysin