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CGS 35066

an endothelin-converting enzyme-1 inhibitor; structure in first source

Also Known As:

3-dibenzofuran-3-yl-2-(phosphonomethylamino)propionic acid; CGS-35066; CGS35066

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - CGS 35066: 2
Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Organophosphonates: 424
    - CGS 35066: 2

Experts

1.	Dai, Zen-Kong: 1 article (06/2006)
2.	Howng, Sheng-Long: 1 article (06/2006)
3.	Jeng, Arco Y: 1 article (06/2006)
4.	Kassell, Neal F: 1 article (06/2006)
5.	Kwan, Aij-Lie: 1 article (06/2006)
6.	Lin, Chih-Lung: 1 article (06/2006)
7.	Su, Yu-Feng: 1 article (06/2006)
8.	Wang, Chih-Jen: 1 article (06/2006)
9.	Winardi, Daniel: 1 article (06/2006)
10.	Winardi, William: 1 article (06/2006)

Related Diseases

1.	Intracranial Vasospasm 06/01/2006 - "These findings suggest that CGS 35066 is a promising therapeutic agent for the prevention and reversal of cerebral vasospasm after SAH. " 06/01/2006 - "The goal of this study was to evaluate the effect of continuous intravenous infusion of a highly selective endothelin-converting enzyme-1 inhibitor, CGS 35066, on the prevention and reversal of cerebral vasospasm following SAH. "
2.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 06/01/2006 - "Prevention and reversal of vasospasm and ultrastructural changes in basilar artery by continuous infusion of CGS 35066 following subarachnoid hemorrhage."
3.	Pulmonary Hypertension 11/01/2004 - "The role of the endothelin (ET) system, known to be involved in pulmonary hypertension of various etiologies, was investigated by evaluating the effect of the four classes of ET blockers: ET-converting enzyme inhibitor (ECEi) (CGS 35066), selective endothelin-A receptor antagonist (ETA-Ra) (Atrasentan, ABT-627), endothelin-B receptor antagonist (ETB-Ra) (A-192621) or mixed endothelin-A/endothelin-B receptor antagonist (ETA/B-Ra) (A-182086) in this animal model. "

Related Drugs and Biologics

1.	Endothelins (Endothelin)
2.	Endothelin B Receptor
3.	Endothelin A Receptor
4.	Enzyme Inhibitors (Inhibitors, Enzyme)

Related Therapies and Procedures

1.	Intravenous Infusions