|1.||Nikiforuk, Agnieszka: 2 articles (01/2013 - 12/2006)|
|2.||Granados-Soto, Vinicio: 2 articles (10/2011 - 03/2011)|
|3.||Rocha-González, Héctor I: 2 articles (10/2011 - 03/2011)|
|4.||Castañeda-Corral, Gabriela: 2 articles (10/2011 - 03/2011)|
|5.||Branco, Luiz G S: 2 articles (08/2006 - 05/2005)|
|6.||Gargaglioni, Luciane H: 2 articles (08/2006 - 05/2005)|
|7.||Ki, H G: 1 article (07/2014)|
|8.||Bae, H B: 1 article (07/2014)|
|9.||Choi, J I: 1 article (07/2014)|
|10.||Lee, H G: 1 article (07/2014)|
12/28/2006 - "Importantly, the anxiolytic- and antidepressant-like activity of SB 269970 seemed to be specific, since that agent - when given by the same route in doses effective in either model - affected neither the shock threshold, nor the non-punished water consumption, nor the exploratory activity of rats. "
12/01/2011 - "LP44-induced (20.5 nmol) hypothermia was significantly attenuated by the selective 5-HT(7) receptor antagonist SB 269970 (16.1 fmol, i.c.v.) pretreatment. "
12/01/2008 - "WAY 100635 and SB 269970 together completely blocked 5-HTP-induced hypothermia in SERT+/- and -/- mice. "
12/01/2008 - "The 5-HT1A antagonist WAY 100635 decreased 5-HTP-induced hypothermia in SERT+/+ and +/- mice with no effect in SERT-/- mice, whereas the 5-HT7 antagonist SB 269970 decreased this exaggerated response in SERT-/- mice only. "
08/14/2006 - "In the first part of our study, acute administration of SB-269970 (0.1-1 mg/kg, i.p.), a potent and selective 5-HT(7) receptors antagonist, dose-dependently prevented 5-HT(1A/7) receptor agonist 8-OH-DPAT (0.1 mg/kg, s.c.)-induced hypothermia and when the 5-HT(1A) receptor antagonist WAY-100,635 was co-injected with SB-269970, a reduction of the latter hypothermia was obtained in an additive manner. "
10/01/2011 - "Systemic (0.01-10mg/kg) or spinal (0.3-30 μg) administration of the selective 5-HT(7) receptor antagonist SB-269970 but not vehicle reduced in a dose-dependent manner established tactile allodynia. "
11/01/2013 - "The 5-HT7 R antagonist SB-269970 exhibited antidepressant-like activity, whereas systemic administration of the 5-HT7 R agonist AS-19 significantly inhibited mechanical hypersensitivity and thermal hyperalgesia. "
07/14/2009 - "In contrast, hyperalgesia induced by RVM-CCK was blocked by spinal ondansetron, but not by SB-269970. "
07/01/2014 - "Effects of intrathecal (i.t.) AS-19 (5-HT7R agonist) and SB-269970 (5-HT3R antagonist) on flinching response in the formalin test and mechanical allodynia in the carrageenan model were evaluated in male Sprague-Dawley rats. "
10/11/2012 - "post-treatment (6 days after formalin injection) with GR-125487, SB-258585 and SB-269970 reversed formalin-induced secondary allodynia and hyperalgesia in both paws. "
|4.||Schizophrenia (Dementia Praecox)
12/01/2006 - "There was a significant decrease in the binding of [3H]SB 269970 to the serotonin7 receptor in Brodmann's area 9 from subjects with schizophrenia compared to controls (Mean+/-S.E.M.: 8.3+/-0.76 vs. 11.0+/-0.64 fmol/mg ETE; p<0.05) and an increase in the binding of that radioligand in the cortex of rats treated with haloperidol (p=0.03). "
01/01/2013 - "Because the role of 5-HT7 receptor blockade in ameliorating positive and negative symptoms of schizophrenia remains equivocal, the second aim of these experiments was to examine the effectiveness of SB-269970 and amisulpride in reversing ketamine-induced deficits in prepulse inhibition of the startle reflex and in social interaction test in rats. "
01/01/2013 - "Effects of the selective 5-HT7 receptor antagonist SB-269970 and amisulpride on ketamine-induced schizophrenia-like deficits in rats."
|5.||Hypotension (Low Blood Pressure)
02/15/2005 - "At the highest dose, SB-269970 also attenuated the reflex hypotension and sympathoinhibition. "
10/19/2004 - "Intravenous injections of 5-HT and 5-carboxamidotryptamine (5-CT) elicited a dose-dependent hypotension that was dose-dependently antagonised by (R)-1-[(3-hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl) ethyl] pyrrolidine (SB-269970; a selective 5-HT7 receptor antagonist), but not by saline. "
|2.||5-HT1A Serotonin Receptor
|6.||Serotonin (5 Hydroxytryptamine)
|9.||serotonin 7 receptor