IL-TIF IL-10-related T cell-derived inducible factor

a 20-kDa cytokine structurally related to IL-10 and inducible by IL-9; has 22% identity with IL-10; amino acid sequence in first fource; GenBank AJ249491-2

Also Known As:

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dumoutier, L: 2 articles (08/2000 - 02/2000)
2.	Renauld, J C: 2 articles (08/2000 - 02/2000)
3.	Alloza, Iraide: 1 article (07/2002)
4.	Billiau, Alfons: 1 article (07/2002)
5.	Brehmer, Dirk: 1 article (07/2002)
6.	McFerran, Neil: 1 article (07/2002)
7.	Proost, Paul: 1 article (07/2002)
8.	Rüdiger, Stefan: 1 article (07/2002)
9.	Vandenbroeck, Koen: 1 article (07/2002)
10.	Walker, Brian: 1 article (07/2002)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 02/01/2002 - "A family of interleukin-10 (IL-10)-related cytokines has emerged, comprising a series of herpesviral and poxviral members and several cellular sequence paralogs, including IL-19, IL-20, IL-22 [IL-10-related T-cell-derived inducible factor (IL-TIF)], IL-24 [melanoma differentiation-associated antigen 7 (MDA-7)] and IL-26 (AK155). " 07/12/2002 - "The helix C DnaK-binding site appears to be conserved in most members of the superfamily of interleukin (IL)-10-related cytokines that comprises, apart from IL-10 and IFN-gamma, a series of recently discovered small secretory proteins, including IL-19, IL-20, IL-22/IL-TIF, IL-24/MDA-7 (melanoma differentiation-associated gene), IL-26/AK155, and a number of viral IL-10 homologs. "
2.	Psoriasis (Pustulosis Palmaris et Plantaris) 02/01/2002 - "For example, whereas IL-10 is a well-studied pleiotropic immunosuppressive and immunostimulatory cytokine, IL-22/IL-TIF mediates acute-phase response signals in hepatocytes and IL-20 induces the hyperproliferation of keratinocytes, which has been proposed as a pathogenic mechanism of psoriasis."
3.	Lymphoma (Lymphomas) 02/15/2000 - "This protein, designated IL-10-related T cell-derived inducible factor (IL-TIF), is induced by IL-9 in thymic lymphomas, T cells, and mast cells, and by lectins in freshly isolated splenocytes. "
4.	Hepatocellular Carcinoma (Hepatoma) 08/29/2000 - "Recombinant human IL-TIF was found to activate signal transducer and activator of transcription factors-1 and -3 in several hepatoma cell lines. " 08/29/2000 - "IL-TIF stimulation of HepG2 human hepatoma cells up-regulated the production of acute phase reactants such as serum amyloid A, alpha1-antichymotrypsin, and haptoglobin. "
5.	Acute-Phase Reaction 02/01/2002 - "For example, whereas IL-10 is a well-studied pleiotropic immunosuppressive and immunostimulatory cytokine, IL-22/IL-TIF mediates acute-phase response signals in hepatocytes and IL-20 induces the hyperproliferation of keratinocytes, which has been proposed as a pathogenic mechanism of psoriasis."

Related Drugs and Biologics

1.	Interleukin-10 (Interleukin 10)
2.	Cytokines
3.	Proteins (Proteins, Gene)
4.	interleukin 20 (IL-20)
5.	Lectins
6.	Interleukin-9 (Interleukin 9)
7.	Interleukins
8.	Haptoglobins
9.	Antigens
10.	Serum Amyloid A Protein (Serum Amyloid A)