|1.||Eilon, G F: 1 article (01/2000)|
|2.||Gu, J: 1 article (01/2000)|
|3.||Slater, L M: 1 article (01/2000)|
|4.||Hara, K: 1 article (01/2000)|
|5.||Jacobs, J W: 1 article (01/2000)|
01/01/2000 - "A final objective of this study was to establish if NCO-700 and TOP-008 achieved cancer cell killing through an apoptotic mechanism. "
01/01/2000 - "These studies indicated that the epoxide-containing piperazines, as exemplified by NCO-700 and TOP-008, were effective anti-cancer agents when tested in vitro and in vivo against human breast and prostate tumors. "
01/01/2000 - "The anti-proliferative activity of NCO-700 and TOP-008 were tested in a 7 day cell-survival assay utilizing a number of well characterized breast (HS-578T, T47D, MCF-7) and prostate (DU-145, PC-3, LNCaP) cancer cell lines. "
|2.||Breast Neoplasms (Breast Cancer)
01/01/2000 - "NCO-700 and TOP-008 displayed cytotoxicity to HS-578T human breast cancer cells, with ED(50) values in the 3-6 microM range. "
01/01/2000 - "The mechanism of cytotoxicity was shown to be through apoptosis, (a) by confocal microscopy studies revealing nuclear fragmentation, (b) by mitochondrial studies revealing disruption of the mitochondrial membrane and release of the cationic dye, JC-1, into the cytoplasm and (c) by protein immunoblot assays indicating that over a 6 h period, TOP-008 induced a significant accumulation of the pro-apoptotic protein, bak, in the mitochondrial fraction of HS-578T human breast cancer cells, accompanied by activation, at 2.5 h, of caspase-3. "
|3.||Prostatic Neoplasms (Prostate Cancer)
|1.||Caspase 3 (Caspase-3)
|3.||5,5',6,6'- tetrachloro- 1,1',3,3'- tetraethylbenzimidazolocarbocyanine
|6.||A 7 (A-7)