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SB 227122

structure in first source

Also Known As:

7-diisopropylaminocarbonyl-8,14-dimethyl-4-hydroxy-3-methoxy-4b,5,9,9a,10,11-hexahydro-(6H)-(2,3-h)-pyrrolo(10,4-b)iminoethenophenanthrene; SB-227122

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dondio, G: 1 article (02/2000)
2.	Giardina, G: 1 article (02/2000)
3.	Hay, D W: 1 article (02/2000)
4.	Kotzer, C J: 1 article (02/2000)
5.	Petrillo, P: 1 article (02/2000)
6.	Underwood, D C: 1 article (02/2000)

Related Diseases

1.

02/01/2000 - "These studies provide compelling evidence that the antitussive effects of SB 227122 in this guinea pig cough model are mediated by agonist activity at the delta-opioid receptor."
02/01/2000 - "In this study, the activity of the delta-opioid receptor subtype-selective agonist, SB 227122, was investigated in a guinea pig model of citric acid-induced cough. "
02/01/2000 - "Parenteral administration of selective agonists of the delta-opioid receptor (SB 227122), mu-opioid receptor (codeine and hydrocodone), and kappa-opioid receptor (BRL 52974) produced dose-related inhibition of citric acid-induced cough with ED(50) values of 7.3, 5.2, 5.1, and 5.3 mg/kg, respectively. "

Related Drugs and Biologics

1.	Citric Acid (Citrate)
2.	delta Opioid Receptors (delta Opioid Receptor)
3.	Antitussive Agents (Antitussives)
4.	kappa Opioid Receptors (kappa Opioid Receptor)
5.	mu Opioid Receptors (mu Opioid Receptor)
6.	Hydrocodone (Dihydrocodeinone)
7.	Codeine (Codeine Phosphate)
8.	BRL 52974