|1.||Rehni, Ashish K: 2 articles (12/2013 - 08/2013)|
|2.||Crist, K A: 2 articles (12/2000 - 01/2000)|
|3.||You, M: 2 articles (12/2000 - 01/2000)|
|4.||Lantry, L E: 2 articles (12/2000 - 01/2000)|
|5.||Zhang, Z: 2 articles (12/2000 - 01/2000)|
|6.||Lubet, R A: 2 articles (12/2000 - 01/2000)|
|7.||Wang, Y: 2 articles (12/2000 - 01/2000)|
|8.||Singh, Thakur G: 1 article (12/2013)|
|9.||Arora, Sandeep K: 1 article (12/2013)|
|10.||Singh, Thakur Gurjeet: 1 article (08/2013)|
01/01/2000 - "Moreover, FTI-276 treatment resulted in a significant reduction in tumor volume (approximately 58%). "
09/18/2003 - "In the late treatment study, where mice were treated with an inhibitor 12 to 20 weeks after carcinogen administration, FTI-276 treatment resulted in a 60% reduction in tumor multiplicity and 58% reduction in tumor volume. "
12/01/2000 - "In summary, we have shown that POH and FTI-276 are chemopreventive in a primary mouse lung tumor model. "
12/01/2000 - "Finally, FTI-276 reduced both the tumor multiplicity by 41.7% (P < .005), and the total tumor volume/burden per mouse by 79.4% (P < .0001). "
03/01/1998 - "Furthermore, FTI-276 inhibits tumor growth of NIH3T3 cells transformed by a form of oncogenic H-Ras that is exclusively geranylgeranylated and whose processing is resistant to this inhibitor. "
08/01/2013 - "Therefore, the present study investigated the effect of GGTI-2133 and FTI-276 on propagation of morphine dependence and resultant withdrawal signs in vivo, in sub-chronic morphine mouse model, and in vitro, in isolated rat ileum. "
08/01/2013 - "It is concluded that GGTI-2133 and FTI-276 attenuate the propagation of morphine dependence and reduce withdrawal signs possibly by a geranylgeranyl transferase; farnesyltransferase activation pathway linked mechanisms potentially in an interdependent manner."
10/01/1995 - "In contrast, FTI-276 did not inhibit tumor growth of a human lung carcinoma that harbors no Ras mutations. "
10/01/1995 - "FTI-276 blocked the growth in nude mice of a human lung carcinoma that expresses the two most prevalent genetic alterations in human cancers (K-Ras oncogenic mutation and deletion in the tumor suppressor gene p53). "
10/01/1995 - "Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion."
09/01/1997 - "B1086, L-739,749, L-744,832 and FTI-276, which are CAAX analogs, were reported to show inhibition of tumor growth in ras-mutated human tumor xenograft models and to induce regression of mammary and salivary carcinoma in ras transgenic mouse model. "
12/01/2013 - "FTI-276 trifluoroacetate treatment markedly and dose-dependently attenuated the precipitated nicotine withdrawal syndrome, measured by a composite withdrawal severity score, jumping frequency, hyperalgesia in the tail flick test, and anxiety-like behavior in the elevated plus maze test. "
|1.||Morphine (MS Contin)
|3.||lonafarnib (SCH 66336)
|6.||Trifluoroacetic Acid (Trifluoroacetate)
|2.||Heterologous Transplantation (Xenotransplantation)