|1.||Miwa, Nobuhiko: 2 articles (12/2003 - 06/2002)|
|2.||Nagao, Norio: 1 article (12/2003)|
|3.||Liu, Jian-Wen: 1 article (12/2003)|
|4.||Masatsuji-Kato, Eiko: 1 article (12/2003)|
|5.||Kayasuga, Atsushi: 1 article (12/2003)|
|6.||Tuzuki, Toshi: 1 article (12/2003)|
|7.||Wei, Dong Zhi: 1 article (06/2002)|
|8.||Liu, Jian Wen: 1 article (06/2002)|
|9.||Du, Chang Bin: 1 article (06/2002)|
|10.||Miwa, N: 1 article (01/2000)|
06/01/2002 - "In the present study, the mechanism underlying the inhibitory effect of Asc2P6Plm on invasion of human fibrosarcoma cells HT-1080 was attempted to be analysed. "
12/01/2003 - "Our previous study showed that tumor invasion of human fibrosarcoma cells HT-1080 is hardly inhibited by ascorbic acid itself (Asc), but inhibited by 2-O-phosphorylated Asc-6-O-palmitylester (Asc2P6Plm) more markedly than 2-O-phosphorylated Asc or Asc-6-O-palmitylester, and that the inhibitory effect may be attributed to an increase in intracellular Asc derived from Asc2P6Plm. "
01/01/1999 - "A lipophilic and auto-oxidation-resistant derivative of ascorbic acid (Asc), Asc-2-O-phosphate-6-O-palmitate (Asc2P6Plm), was shown to exert an invasion-inhibitory action as promptly as 30-40 min for 50% inhibition and 60-90 min for 80% inhibition after entering fibrosarcoma HT-1080 cells. "
01/01/2000 - "The invasion of human fibrosarcoma HT-1080 cells through Matrigel was shown to be inhibited by pretreatment with ascorbic acid (Asc) or its four derivatives, such as Asc-6-O-palmitate (Asc6Plm), Asc-2-O-phosphate (Asc2P), Asc-2-O-phosphate-6-O-palmitate (Asc2P6Plm), and Asc-5,6-benzylidene (Asc5,6Bz) of non-cytotoxic concentrations for 1 or 18 hr. Two lipophilic derivatives such as Asc6Plm and Asc2P6Plm exerted an invasiveness-inhibitory activity more markedly with 1-hr pretreatment, being a more practical index in terms of the plasma half-life, than Asc, Asc5,6Bz or Asc2P being less lipophilic. "
12/01/2003 - "In the present study, the mechanism underlying the inhibitory effect of Asc2P6Plm on tumor invasion was analyzed. "
06/01/2002 - "Our previous study shows that tumor invasion is inhibited by 2-O-phosphorylated ascorbate-6-O-palmitylester (Asc2P6Plm). "
12/01/2003 - "Thus the inhibition of tumor invasion by Asc2P6Plm was shown to be attributed to decrease in both the cell migratory ability and the actin localization near the cell membrane, which may result from an increase in cytoplasmic RhoA and reduction of intracellular ROS that is achieved by enrichment of intracellular Asc derived from Asc2P6Plm."
01/01/2000 - "Thus Asc2P6Plm, a lipophilicity-hydrophilicity balanced molecule protectively blockd in the autooxidation-prone moiety, is anticipated as a potent anti-metastatic agent via inhibition of tumor invasion."
12/01/2003 - "Migratory ability of the tumor cells was shown to be inhibited in a dose-dependent manner by either treatment with Asc2P6Plm at 50-300 micro M for 1 h or at 10-50 micro M for 18 h as assessed by cell sheet scratching assay. "
|3.||Melanoma (Melanoma, Malignant)
01/01/1999 - "Antimetastatic effects on melanoma B16BL6 cells were given dose dependently by intravenous administration or pretreatment with Asc2P6Plm. "
01/01/2000 - "Pulmonary metastasis of mouse melanoma B16BL6 cells injected into the tail vein was also inhibited by intravenous administration with Asc2P6Plm dose-dependently. "
|4.||Neoplasm Metastasis (Metastasis)
|5.||Ehrlich Tumor Carcinoma
09/01/1999 - "When Ehrlich ascites tumor cells were treated with 50 microM Asc2P6Pal at 37 degrees C or 42 degrees C for 1 h and then cultured for 20 h, most of cells exhibited some morphological abnormalities, including exudation of intracellular granules together with other contents on the cell membrane surface, resulting in cell fragmentation. "
|1.||Ascorbic Acid (Vitamin C)
|4.||Dihydrotachysterol (AT 10)
|5.||Actins (F Actin)
|8.||6-O-palmitoylascorbic acid (ascorbyl palmitate)