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CGP 53506

inhibitor of of Protein Kinase C-alpha

Also Known As:

CGP53506; N-(3-nitrophenyl)-4-(3-pyridyl)-2-pyrimidinamine

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - CGP 53506: 1

Related Diseases

1.	Neoplasms (Cancer) 09/01/1999 - "The PKC alpha selective inhibitor CGP 53506 reduced the proliferation rate of PKC alpha overexpressing NIH3T3 cells more than that of wild-type cells and induced apoptosis, indicating that such a PKC alpha inhibitor may be useful in the treatment of tumors overexpressing PKC alpha such as glioblastomas. "
2.	Glioblastoma (Glioblastoma Multiforme) 09/01/1999 - "The PKC alpha selective inhibitor CGP 53506 reduced the proliferation rate of PKC alpha overexpressing NIH3T3 cells more than that of wild-type cells and induced apoptosis, indicating that such a PKC alpha inhibitor may be useful in the treatment of tumors overexpressing PKC alpha such as glioblastomas. "