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cynandione A

isolated from Cynanchum wilfordii; structure in first source

Networked: 7 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        cynandione A: 7

Experts

1.	Liu, Hao: 3 articles (01/2021 - 05/2017)
2.	Wang, Yong-Xiang: 3 articles (01/2021 - 05/2017)
3.	Han, Qiao-Qiao: 2 articles (01/2021 - 01/2020)
4.	Shan, Lei: 2 articles (01/2015 - 05/2012)
5.	Yue, Rongcai: 2 articles (01/2015 - 05/2012)
6.	Ali, Usman: 1 article (01/2021)
7.	Deng, Meng-Yan: 1 article (01/2021)
8.	Li, Xin-Yan: 1 article (01/2021)
9.	Ao, Jun-Ping: 1 article (01/2020)
10.	Wang, Zi-Ying: 1 article (01/2020)

Related Diseases

1.	Brain Ischemia (Cerebral Ischemia) 05/01/2012 - "Furthermore, rats with cerebral ischemia treated with 30 mg/kg cynandione A exhibited markedly improved neurological deficit scores at 24 and 72 h compared with control and a 7.2% reduction in cerebral infarction size at 72 h (p < 0.05 vs. control). " 05/01/2012 - "Cynandione A mitigates ischemic injuries in rats with cerebral ischemia." 05/01/2012 - "auriculatum in pheochromocytoma tumor cell line PC12 and investigate whether cynandione A protected against ischemic injuries in rats with experimentally induced cerebral ischemia. " 05/01/2012 - "Immunoblotting studies showed that 10 μM cynandione A aborted glutamate-induced increase in DPYSL2 and HMGB1 levels in PC12 cells and 30 mg/kg cynandione A also attenuated the rise in HMGB1 levels and mitigated DPYSL2 cleavage in brain tissues of rats with cerebral ischemia. "
2.	Cerebral Infarction 05/01/2012 - "Furthermore, rats with cerebral ischemia treated with 30 mg/kg cynandione A exhibited markedly improved neurological deficit scores at 24 and 72 h compared with control and a 7.2% reduction in cerebral infarction size at 72 h (p < 0.05 vs. control). "
3.	Pain (Aches) 01/01/2020 - "This study further explored the target molecule and signaling mechanisms underlying cynandione-A-induced antineuropathic pain. " 01/01/2020 - "Cynandione A, an acetophenone isolated from Cynanchum Wilfordii Radix, exhibits antineuropathic pain effect. " 05/12/2023 - "In addition, molecules such as gabapentinoids, thalidomide, cynandione A, morroniside, lemairamin, and cinobufagin, as well as non-pharmacological treatments such as electroacupuncture, reduce pain through IL-10 mediated mechanisms, reflecting a microglia-dependent β-endorphin differential increase. "
4.	Ischemic Stroke 01/01/2015 - "Our previous study found that cynandione A (CYNA), the main component from the root of Cynanchum bungei, exhibits anti-ischemic stroke activity. " 01/01/2015 - "Analysis of Cynandione A's Anti-Ischemic Stroke Effects from Pathways and Protein-Protein Interactome." 05/01/2012 - "Our findings demonstrated that cynandione A mitigated ischemic injuries and should be further explored as a neuroprotective agent for ischemic stroke."
5.	Neuralgia (Stump Neuralgia) 01/01/2020 - "These findings suggest that cynandione A suppresses neuropathic pain through α7-nAChR-dependent IL-10/β-endorphin signaling pathway in spinal microglia." 01/01/2020 - "Cynandione A Alleviates Neuropathic Pain Through α7-nAChR-Dependent IL-10/β-Endorphin Signaling Complexes." 05/01/2017 - "These results suggest that cynandione A attenuates neuropathic pain through upregulation of spinal microglial expression β-endorphin via p38β MAPK activation." 05/01/2017 - "Cynandione A attenuates neuropathic pain through p38β MAPK-mediated spinal microglial expression of β-endorphin."

Related Drugs and Biologics

1.	HMGB1 Protein (HMG1)
2.	Glutamic Acid (Glutamate)
3.	Interleukin-10 (Interleukin 10)
4.	Endorphins
5.	acetophenone
6.	Neuroprotective Agents
7.	Thalidomide (Thalomid)
8.	Proteins (Proteins, Gene)
9.	Lipopolysaccharides
10.	Dynorphins (Dynorphin)

Related Therapies and Procedures

1.	Spinal Injections
2.	Electroacupuncture
3.	Ligation