|1.||Doty, Pamela: 13 articles (11/2015 - 01/2007)|
|2.||Stöhr, Thomas: 13 articles (07/2013 - 01/2006)|
|3.||Biton, Victor: 8 articles (11/2015 - 02/2007)|
|4.||Hebert, David: 8 articles (11/2015 - 01/2009)|
|5.||Kohn, Harold: 7 articles (02/2015 - 10/2005)|
|6.||Patsalos, Philip N: 7 articles (08/2014 - 08/2010)|
|7.||Cawello, Willi: 6 articles (09/2015 - 04/2010)|
|8.||Ben-Menachem, Elinor: 6 articles (12/2014 - 07/2007)|
|9.||Fountain, Nathan B: 5 articles (11/2015 - 03/2008)|
|10.||Rosenow, Felix: 5 articles (10/2014 - 03/2009)|
04/01/2012 - "Lacosamide was effective therapy for most seizure types but was particularly effective for partial-onset seizures. "
03/01/2011 - "Patient 2: The add-on medication of lacosamide led to a significant reduction in seizure frequency and to a marked decrease in the mean duration of seizures. "
02/01/2011 - "Lacosamide is a new antiepileptic drug that has a novel mechanism of action, linear pharmacokinetics, and proven efficacy in the adjunctive treatment of partial-onset seizures. "
12/01/2015 - "In clinical trials, adjunctive lacosamide provided significantly greater reductions in 28-day seizure rates than adjunctive placebo, with these benefits maintained after up to 8 years of therapy in open-label extension studies. "
12/01/2013 - "In three randomized, double-blind, placebo-controlled, multicentre studies in adults and adolescents (aged 16-18 years) with partial-onset seizures, adjunctive therapy with oral lacosamide (administered for an initial titration period followed by 12 weeks' maintenance therapy) generally reduced the frequency of seizures to a significantly greater extent than placebo, with antiepileptic efficacy sustained following longer-term treatment (up to 8 years) in this patient population. "
|2.||Partial Epilepsies (Epilepsy, Partial)
07/01/2014 - "Lacosamide 400 mg/day monotherapy was effective, with a favorable safety profile in patients with focal epilepsy."
10/01/2015 - "Lacosamide is a well-tolerated newer antiepileptic drug that is effective in refractory partial epilepsy paediatric patients and concurrently improved patient's behaviour."
06/01/2014 - "Lacosamide represents a useful drug that is effective for a wide range of pediatric refractory focal epilepsy and is well tolerated."
12/01/2015 - "Our study adds evidence that lacosamide appears to be a safe and effective adjunctive therapy for children with refractory focal epilepsy. "
01/30/2015 - "A retrospective study in adult partial epilepsy on the efficacy of lacosamide in relation to previous antiepileptic drug experiences. "
|3.||Status Epilepticus (Complex Partial Status Epilepticus)
11/01/2011 - "While lacosamide has been reported as an effective treatment for refractory status epilepticus, there is insufficient evidence for its routine use. "
09/01/2011 - "Experimental data and recent reports suggest that lacosamide could be effective in status epilepticus. "
03/01/2013 - "Lacosamide as a new treatment option in status epilepticus."
04/01/2013 - "Safety and efficacy of intravenous lacosamide for adjunctive treatment of refractory status epilepticus: a comparative cohort study."
01/01/2013 - "Efficacy of intravenous lacosamide as an add-on treatment in refractory status epilepticus: a multicentric prospective study."
05/01/2007 - "Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy."
12/01/2012 - "The results of this study provide preliminary evidence for the efficacy of lacosamide in children with refractory epilepsy. "
07/01/2011 - "Three randomised, multicentre, double-blind, placebo-controlled trials have investigated the efficacy of lacosamide in 1300 adults with epilepsy. "
01/01/2009 - "The efficacy of lacosamide has been shown in animal models of epilepsy and Phase II/III clinical trials. "
01/01/2014 - "Efficacy of lacosamide as adjunctive therapy in children with refractory epilepsy."
06/01/2009 - "The lacosamide 400 mg/d group demonstrated statistically significant improvement in Likert pain score over placebo for the primary efficacy measure. "
02/01/2012 - "In the three cases, the administration of intravenous lacosamide has led to a considerable improvement in pain. "
04/01/2007 - "Antihyperalgesic efficacy of lacosamide in a rat model for muscle pain induced by TNF."
09/01/2010 - "The data relating to the pain relieving effect of lacosamide are sparse. "
09/01/2010 - "The available preclinical and clinical data for the pain relieving effect of lacosamide have been examined using the papers published and referenced on Medline between 1990 and present. "
|1.||Anticonvulsants (Antiepileptic Drugs)
|3.||Valproic Acid (Valproate, Semisodium)
|7.||D 23129 (retigabine)
|1.||Vagus Nerve Stimulation
|3.||Psychology Biofeedback (Biofeedback)
|4.||Renal Dialysis (Hemodialysis)
|5.||Drug Therapy (Chemotherapy)