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tacrolimus binding protein 1B

a 12.6 KD FK-506 binding protein; closely related to TACROLIMUS BINDING PROTEIN 1A
Also Known As:
FK506-binding protein 1B; FKBP12.6; calstabin 2 protein, human
Networked: 63 relevant articles (6 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Dai, Yin: 11 articles (01/2012 - 06/2006)
2. Dai, De-Zai: 10 articles (01/2012 - 01/2006)
3. Wehrens, Xander H T: 6 articles (02/2012 - 05/2003)
4. Rouet-Benzineb, Patricia: 5 articles (01/2013 - 02/2007)
5. Mercadier, Jean-Jacques: 5 articles (01/2013 - 02/2007)
6. Lai, F Anthony: 4 articles (10/2013 - 04/2004)
7. Pezet, Mylène: 4 articles (01/2013 - 04/2008)
8. Chen, S R Wayne: 4 articles (07/2010 - 03/2004)
9. Marks, Andrew R: 4 articles (04/2004 - 05/2003)
10. Gellen, Barnabas: 3 articles (01/2013 - 04/2008)

Related Diseases

1. Heart Failure
06/01/2001 - "Recently, a novel mechanism of cardiac dysfunction in heart failure has been reported on the basis of the following findings:1) PKA hyperphosphorylation of RyR causes a dissociation of FKBP12.6 from RyR, resulting in the abnormal single-channel properties (increased Ca(2+) sensitivity for activation and elevated channel activity associated with destabilization of RyR (Marx et al, Cell 101:365, 2000), 2) a prominent abnormal Ca(2+) leak occurs through RyR, following a partial loss of RyR-bound FKBP12.6 and the resultant conformational change in RyR (Yano M et al, Circulation 102:2131, 2000). "
10/24/2000 - "The level of protein expression of FKBP12.6 was indeed found to be significantly decreased in failing SR. An abnormal Ca(2+) leak through the RyR is present in heart failure, and this leak is presumably caused by a partial loss of RyR-bound FKBP12.6 and the resultant conformational change in RyR. "
01/01/2006 - "A thorough understanding of the structural basis of RyR2-FKBP12.6 interaction should aid in understanding the roles that have been proposed for FKBP12.6 in heart failure and in certain forms of sudden cardiac death."
05/01/2012 - "These findings demonstrate that conditional deletion of CHF1/Hey2 in the myocardium leads to abnormalities in calcium handling mediated by FKBP12.6 that predispose to pressure overload-induced heart failure."
05/01/2012 - "Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6."
2. Cardiac Arrhythmias (Arrythmia)
3. Asthma (Bronchial Asthma)
4. Anoxia (Hypoxia)
5. Cardiomyopathies (Cardiomyopathy)

Related Drugs and Biologics

1. Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)
2. Tacrolimus Binding Proteins (FKBP)
3. Isoproterenol (Isoprenaline)
4. CPU0213
5. Calcium
6. Protein Kinase C-epsilon
7. NADPH Oxidase (NAD(P)H oxidase)
8. 1- (methanesulfonamido- 1- naphthyloxy)- 2- (N- (4- methane sulfonamidophenethyl)-N-acetamido)ethane
9. dofetilide (Tikosyn)
10. Leptin