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3-hydroxysteroid dihydrodiol dehydrogenase

member of the aldo-keto reductase (AKR) superfamily; amino acid sequence has been determined

Also Known As:

3alpha-HSD DD enzyme; AKR1C9

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - Hydroxysteroid Dehydrogenases: 313
        3-hydroxysteroid dihydrodiol dehydrogenase: 2

Experts

1.	Buncek, Martin: 1 article (07/2009)
2.	Gavelová, Martina: 1 article (07/2009)
3.	Kozubík, Alois: 1 article (07/2009)
4.	Krcmár, Pavel: 1 article (07/2009)
5.	Machala, Miroslav: 1 article (07/2009)
6.	Procházková, Jirina: 1 article (07/2009)
7.	Radilová, Hana: 1 article (07/2009)
8.	Skálová, Lenka: 1 article (07/2009)
9.	Szotáková, Barbora: 1 article (07/2009)
10.	Trilecová, Lenka: 1 article (07/2009)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 07/01/2001 - "In this study, rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (AKR1C9) was stably transfected into human breast carcinoma (MCF-7) cells, which represent a null-environment for AKR expression, to detect the formation of PAH o-quinones in a cellular context and the cellular consequences of o-quinone formation. "
2.	Hepatocellular Carcinoma (Hepatoma) 07/15/2009 - "Moreover, constitutive AKR1C9 levels in AhR-deficient rat BP8 hepatoma cells were significantly lower than in their AhR-positive 5L variant, thus supporting possible role of AhR in regulation of AKR1C9 expression. "

Related Drugs and Biologics

1.	Quinones
2.	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (dihydrodiol dehydrogenase)
3.	quinone (benzoquinone)